Novel thiadiazole-thiazole hybrids: synthesis, molecular docking, and cytotoxicity evaluation against liver cancer cell lines
One of the worst diseases, cancer claims millions of lives each year throughout the world,
necessitating the creation of novel treatments. In this study, we designed a novel series of 1 …
necessitating the creation of novel treatments. In this study, we designed a novel series of 1 …
Identification of novel 4-thiazolidinones as new TcaR inhibitors: Design, synthesis, molecular docking, MD simulation, ADMET and in vitro antibacterial evaluation
MD Vaghasiya, JV Mendapara, SP Vaghasiya… - Journal of Molecular …, 2023 - Elsevier
Novel morpholine and piperazine-containing 4-thiazolidinone derivatives (6a-6e) and (7a-
7e) were designed and synthesized utilizing a multi-component reaction (MCR) to develop …
7e) were designed and synthesized utilizing a multi-component reaction (MCR) to develop …
Synthesis, spectroscopic (IR and NMR), HOMO-LUMO, NLO, molecular docking and ADME study of (E)-2-(2-((5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl) methylene) …
The three component reaction between 5‑chloro-3-methyl-1-phenyl-1H-pyrazole-4-
carbaldehyde, thiosemicarbazide and 4-nitrophenacyl bromide furnished (E)-2-(2-((5‑chloro …
carbaldehyde, thiosemicarbazide and 4-nitrophenacyl bromide furnished (E)-2-(2-((5‑chloro …
Reactions and Biological Activities of Hydrazonoyl Halides
MF Alarbash, YS Al-Faiyz, JS Wiggins… - Current Organic …, 2024 - ingentaconnect.com
This review covers the literature information on the chemistry of hydrazonoyl halides with
different substrates to give heterocyclic compounds. From the foregoing survey, it seems this …
different substrates to give heterocyclic compounds. From the foregoing survey, it seems this …
Synthesis and biological evaluation of thiazole and thiadiazole derivatives as potential anticancer agents
S Ekrek, S Şenkardeş, Ö Erdoğan… - Phosphorus, Sulfur, and …, 2023 - Taylor & Francis
A new series of 4-methyl-2-{2-[(aryl) methylidene] hydrazinyl}-1, 3-thiazole (2a-i), N-(4-acetyl-
5-aryl) 4, 5-dihydro-1, 3, 4-thiadiazol-2-yl) acetamides (3a-b) and N-(5-(4-(substituted …
5-aryl) 4, 5-dihydro-1, 3, 4-thiadiazol-2-yl) acetamides (3a-b) and N-(5-(4-(substituted …
Fluorenone–thiazolidine-4-one scaffolds as antidiabetic and antioxidant agents: design, synthesis, X-ray crystal structures, and binding and computational studies
MA Doddagaddavalli, VKA Kalalbandi… - New Journal of …, 2023 - pubs.rsc.org
Using 2-(9H-fluoren-9-ylidene) hydrazinyl) thiazol-4 (5H)-one and substituted
benzaldehydes, a new library of fluorenone–thiazolidine-4-one scaffolds (5a–u) were …
benzaldehydes, a new library of fluorenone–thiazolidine-4-one scaffolds (5a–u) were …
Synthesis of novel (R)-carvone-tagged thiazolidinone as anticancer leads: characterization, in vitro antiproliferative evaluation and in silico studies
This work describes the successful synthesis of a series of three novel thiazolidinone-
carvone-O-alkyl hybrids through a two-step approach involving heterocyclization and O …
carvone-O-alkyl hybrids through a two-step approach involving heterocyclization and O …
Synthesis of New carbazole–thiazole analogues and evaluating their anticancer activity
Medicinal research has focused on the discovery and progress of anticancer drugs.
Carbazole and thiazole are organic heterocyclic compounds that are the building blocks for …
Carbazole and thiazole are organic heterocyclic compounds that are the building blocks for …
Synthesis, DPPH Radical Scavenging, Cytotoxic Activity, and Apoptosis Induction Efficacy of Novel Thiazoles and Bis-thiazoles
Background: Heterocyclic materials-containing thiazoles exhibited incredible importance in
pharmaceutical chemistry and drug design due to their extensive biological properties …
pharmaceutical chemistry and drug design due to their extensive biological properties …
Synthesis, characterization, and anticancer evaluation of novel 4‐hydrazinothiazole analogs
SY Break, A Hossan, A Farouk - Luminescence, 2023 - Wiley Online Library
Single‐step synthesis of novel 4‐hydrazinothiazole derivatives 6a–e was achieved under
mild conditions using the sequential four‐components method involving isothiocyanate …
mild conditions using the sequential four‐components method involving isothiocyanate …