Novel thiadiazole-thiazole hybrids: synthesis, molecular docking, and cytotoxicity evaluation against liver cancer cell lines

GF Aljohani, TZ Abolibda, M Alhilal… - Journal of Taibah …, 2022 - Taylor & Francis
One of the worst diseases, cancer claims millions of lives each year throughout the world,
necessitating the creation of novel treatments. In this study, we designed a novel series of 1 …

Identification of novel 4-thiazolidinones as new TcaR inhibitors: Design, synthesis, molecular docking, MD simulation, ADMET and in vitro antibacterial evaluation

MD Vaghasiya, JV Mendapara, SP Vaghasiya… - Journal of Molecular …, 2023 - Elsevier
Novel morpholine and piperazine-containing 4-thiazolidinone derivatives (6a-6e) and (7a-
7e) were designed and synthesized utilizing a multi-component reaction (MCR) to develop …

Synthesis, spectroscopic (IR and NMR), HOMO-LUMO, NLO, molecular docking and ADME study of (E)-2-(2-((5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl) methylene) …

HS Deshmukh, VA Adole, A Kumar, N Misra… - Journal of Molecular …, 2024 - Elsevier
The three component reaction between 5‑chloro-3-methyl-1-phenyl-1H-pyrazole-4-
carbaldehyde, thiosemicarbazide and 4-nitrophenacyl bromide furnished (E)-2-(2-((5‑chloro …

Reactions and Biological Activities of Hydrazonoyl Halides

MF Alarbash, YS Al-Faiyz, JS Wiggins… - Current Organic …, 2024 - ingentaconnect.com
This review covers the literature information on the chemistry of hydrazonoyl halides with
different substrates to give heterocyclic compounds. From the foregoing survey, it seems this …

Synthesis and biological evaluation of thiazole and thiadiazole derivatives as potential anticancer agents

S Ekrek, S Şenkardeş, Ö Erdoğan… - Phosphorus, Sulfur, and …, 2023 - Taylor & Francis
A new series of 4-methyl-2-{2-[(aryl) methylidene] hydrazinyl}-1, 3-thiazole (2a-i), N-(4-acetyl-
5-aryl) 4, 5-dihydro-1, 3, 4-thiadiazol-2-yl) acetamides (3a-b) and N-(5-(4-(substituted …

Fluorenone–thiazolidine-4-one scaffolds as antidiabetic and antioxidant agents: design, synthesis, X-ray crystal structures, and binding and computational studies

MA Doddagaddavalli, VKA Kalalbandi… - New Journal of …, 2023 - pubs.rsc.org
Using 2-(9H-fluoren-9-ylidene) hydrazinyl) thiazol-4 (5H)-one and substituted
benzaldehydes, a new library of fluorenone–thiazolidine-4-one scaffolds (5a–u) were …

Synthesis of novel (R)-carvone-tagged thiazolidinone as anticancer leads: characterization, in vitro antiproliferative evaluation and in silico studies

Y Riadi, O Afzal, S Kumar, V Varadharajan… - Journal of …, 2024 - Taylor & Francis
This work describes the successful synthesis of a series of three novel thiazolidinone-
carvone-O-alkyl hybrids through a two-step approach involving heterocyclization and O …

Synthesis of New carbazole–thiazole analogues and evaluating their anticancer activity

MR Elmorsy, M Eltoukhi, AA Fadda… - Polycyclic Aromatic …, 2023 - Taylor & Francis
Medicinal research has focused on the discovery and progress of anticancer drugs.
Carbazole and thiazole are organic heterocyclic compounds that are the building blocks for …

Synthesis, DPPH Radical Scavenging, Cytotoxic Activity, and Apoptosis Induction Efficacy of Novel Thiazoles and Bis-thiazoles

A Negm, YS Al-Faiyz, SM Riyadh… - Current Organic …, 2024 - ingentaconnect.com
Background: Heterocyclic materials-containing thiazoles exhibited incredible importance in
pharmaceutical chemistry and drug design due to their extensive biological properties …

Synthesis, characterization, and anticancer evaluation of novel 4‐hydrazinothiazole analogs

SY Break, A Hossan, A Farouk - Luminescence, 2023 - Wiley Online Library
Single‐step synthesis of novel 4‐hydrazinothiazole derivatives 6a–e was achieved under
mild conditions using the sequential four‐components method involving isothiocyanate …