Despite improvements in medical and surgical therapies, infective endocarditis is associated
with poor prognosis and remains a therapeutic challenge. Many factors affect the outcome of …

We performed a meta-analysis of randomised clinical studies in which the efficacy and
toxicity of the same total daily dose of aminoglycosides administered once-daily was …

Background Clinical phage therapy is often delivered alongside antibiotics. However, the
phenomenon of phage-antibiotic synergy has been mostly studied in vitro. Here, we …

With the antibiotic development pipeline running dry, many fear that we might soon run out
of treatment options. High-density infections are particularly difficult to treat due to their …

Objective.—To provide guidelines for the treatment of endocarditis in adults caused by the
following microorganisms: viridans streptococci and other streptococci, enterococci …

We present and analyze a series of mathematical models for the emergence of resistance
during antibiotic treatment of an infected host. The models consider the population dynamics …

The interaction of miltefosine with amphotericin B, sodium stibogluconate, paromomycin,
and sitamaquine was assessed in vitro and additionally for the first three combinations in …

The most appropriate therapy for meningitis caused by Streptococcus pneumoniae strains
resistant to the extended-spectrum cephalosporins is unknown. We evaluated ceftriaxone …

Bactericidal testing has been used for several decades as a guide for antimicrobial therapy
of serious infections. Such testing is most frequently performed when bactericidal …

We are reporting on a nosocomial outbreak of 213 cases of vancomycin-resistant
enterococcus infection involving 2,812 enterococcal isolates from patients over a period of …