For the past two decades since their discovery, scientists have linked microRNAs (miRNAs)
to posttranscriptional regulation of gene expression in critical cardiac physiological and …

In patients with chronic kidney disease (CKD), loss of cellular proteins increases the risks of
morbidity and mortality. Persistence of muscle protein catabolism in CKD results in striking …

PIWI-interacting RNAs (piRNAs) are abundantly expressed during cardiac hypertrophy.
However, their functions and molecular mechanisms remain unknown. Here, we identified a …

Disease is often the result of an aberrant or inadequate response to physiologic and
pathophysiologic stress. Studies over the last 10 years have uncovered a recurring …

Dysregulated autophagy is associated with many pathological disorders such as
cardiovascular diseases. Emerging evidence has suggested that circular RNAs (circRNAs) …

MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …

First recognized as regulators of development in worms and fruitflies, microRNAs are
emerging as pivotal modulators of mammalian cardiovascular development and disease …

Abnormal mitochondrial fission participates in the pathogenesis of many diseases. Long non-
coding RNAs (lncRNAs) are emerging as new players in gene regulation, but how lncRNAs …

Myocardial infarction is a leading cause of mortality worldwide. Here we report that
modulation of microRNA-499 (miR-499) levels affects apoptosis and the severity of …

Cardiovascular disease is the predominant cause of human morbidity and mortality in
developed countries. Thus, extraordinary effort has been devoted to determining the …