Recent advances of liquid biopsy: Interdisciplinary strategies toward clinical decision‐making

H Bao, L Min, F Bu, S Wang… - Interdisciplinary Medicine, 2023 - Wiley Online Library
Liquid biopsy has emerged as a promising avenue for non‐invasive and rapid retrieval of
pathological information from patient body fluids. Over the years, liquid biopsy has garnered …

Hydraulic–electric analogy for design and operation of microfluidic systems

Z Li, C Liu, J Sun - Lab on a Chip, 2023 - pubs.rsc.org
Microfluidic systems have been investigated as practical tools in the fields of biomedical
engineering, analytical chemistry, materials science, and biological research. Yet the …

Direct isolation of small extracellular vesicles from human blood using viscoelastic microfluidics

Y Meng, Y Zhang, M Bühler, S Wang, M Asghari… - Science …, 2023 - science.org
Small extracellular vesicles (sEVs;< 200 nm) that contain lipids, nucleic acids, and proteins
are considered promising biomarkers for a wide variety of diseases. Conventional methods …

EVs‐on‐a‐Bubble: Self‐Aggregated Click Bubbles Streamline Isolation and Amplified Profiling of Circulating Extracellular Vesicles

B Wei, Y Xiang, X Qin, Y Yang, H Lu… - Advanced Functional …, 2024 - Wiley Online Library
Tumor‐derived circulating extracellular vesicles (EVs) provide a non‐invasive solution for
cancer diagnostics, but hampered by challenges in EVs isolation and profiling. Herein, this …

Advanced Nanoencapsulation-Enabled Ultrasensitive Analysis: Unraveling Tumor Extracellular Vesicle Subpopulations for Differential Diagnosis of Hepatocellular …

X Li, Y Liu, Y Fan, G Tian, B Shen, S Zhang, X Fu… - ACS …, 2024 - ACS Publications
Tumor-derived extracellular vesicles (tEVs) hold immense promise as potential biomarkers
for the precise diagnosis of hepatocellular carcinoma (HCC). However, their clinical …

High-Throughput Microfluidic Extraction of Platelet-free Plasma for MicroRNA and Extracellular Vesicle Analysis

SY Leong, WW Lok, KY Goh, HB Ong, HM Tay, C Su… - ACS …, 2024 - ACS Publications
Cell-free RNAs and extracellular vesicles (EVs) are valuable biomarkers in liquid biopsies,
but they are prone to preanalytical variabilities such as nonstandardized centrifugation or ex …

Emerging Microfluidic Tools for Simultaneous Exosomes and Cargo Biosensing in Liquid Biopsy: New Integrated Miniaturized FFF-Assisted Approach for Colon …

V Marassi, S Giordani, A Placci, A Punzo, C Caliceti… - Sensors, 2023 - mdpi.com
The early-stage diagnosis of cancer is a crucial clinical need. The inadequacies of surgery
tissue biopsy have prompted a transition to a less invasive profiling of molecular biomarkers …

Thermophoretic glycan profiling of extracellular vesicles for triple-negative breast cancer management

Y Li, S Zhang, C Liu, J Deng, F Tian, Q Feng… - Nature …, 2024 - nature.com
Triple-negative breast cancer (TNBC) is a highly metastatic and heterogeneous type of
breast cancer with poor outcomes. Precise, non-invasive methods for diagnosis, monitoring …

Microfluidic Device-Based In Vivo Detection of PD-L1-Positive Small Extracellular Vesicles and Its Application for Tumor Monitoring

XZ Cong, J Feng, HJ Zhang, LZ Zhang, TY Lin… - Analytical …, 2024 - ACS Publications
Liquid biopsy is of great significance in tumor early diagnosis and treatment stratification. PD-
L1-positive small extracellular vesicles (PD-L1+ sEVs) are closely related to tumor growth …

Tumor-derived extracellular vesicle drug delivery system for chemo-photothermal-immune combination cancer treatment

Y Bi, J Chen, Q Li, Y Li, L Zhang, L Zhida, F Yuan… - Iscience, 2024 - cell.com
Tumor extracellular vesicles (EVs) demonstrate considerable promise for medication
delivery and tumor targeting owing to their natural long-term blood circulation and tissue …