The advantages and disadvantages of the cytokinesis-block micronucleus method

M Fenech - Mutation Research/Genetic Toxicology and …, 1997 - Elsevier
There is current interest in adopting the micronucleus test instead of metaphase analysis of
chromosomes to assess the in vitro genotoxic potential of chemical and physical agents. In …

Apoptosis in radiation therapy: a double-edged sword

EK Balcer-Kubiczek - Experimental oncology, 2012 - dspace.nbuv.gov.ua
Radiation therapy achieves its therapeutic effects by inducing apoptosis and non-apoptotic
cell death. The aim of this focused review is to highlight the aspects of the cell death …

Evaluation of the antineoplastic activity of guduchi (Tinospora cordifolia) in cultured HeLa cells

GC Jagetia, V Nayak, MS Vidyasagar - Cancer letters, 1998 - Elsevier
Exposure of HeLa cells to 0, 5, 10, 25, 50 and 100 μg/ml of guduchi extracts (methanol,
aqueous and methylene chloride) resulted in a dose-dependent but significant increase in …

Apoptosis, intrinsic radiosensitivity and prediction of radiotherapy response in cervical carcinoma

EL Levine, A Renehan, R Gossiel, SE Davidson… - Radiotherapy and …, 1995 - Elsevier
Apoptosis is an important mechanism of cell death in tumours and it is seen both prior to and
following radiotherapy. In this study patients with proven carcinoma of the cervix had …

Heterogeneity in 2-deoxy-D-glucose–induced modifications in energetics and radiation responses of human tumor cell lines

BS Dwarkanath, F Zolzer, S Chandana, T Bauch… - International Journal of …, 2001 - Elsevier
Purpose: The glucose analog and glycolytic inhibitor, 2-deoxy-D-glucose (2-DG), has been
shown to differentially enhance the radiation damage in tumor cells by inhibiting the …

A proliferation-dependent bystander effect in primary porcine and human urothelial explants in response to targeted irradiation

OV Belyakov, M Folkard, C Mothersill, KM Prise… - British journal of …, 2003 - nature.com
The aim of this study was to test whether radiation-induced bystander effects are involved in
the response of multicellular systems to targeted irradiation. A primary explant technique …

Reasons to reconsider the significance of apoptosis for cancer therapy

M Abend - International journal of radiation biology, 2003 - Taylor & Francis
In recent years, the significance of apoptosis as a process in cell loss from normal tissue and
tumours has been critically reviewed. In addition, the general lack of a correlation between …

Naringin, a grapefruit flavanone, protects V79 cells against the bleomycin‐induced genotoxicity and decline in survival

A Jagetia, GC Jagetia, S Jha - Journal of Applied Toxicology …, 2007 - Wiley Online Library
The effect of naringin, a grapefruit flavonone was studied on bleomycin‐induced genomic
damage and alteration in the survival of cultured V79 cells. Exposure of V79 cells to …

The extreme radiosensitivity of the squamous cell carcinoma SKX is due to a defect in double-strand break repair

U Kasten-Pisula, A Menegakis, I Brammer… - Radiotherapy and …, 2009 - Elsevier
PURPOSE: Squamous cell carcinomas (SCCs) are characterized by moderate
radiosensitivity. We have established the human head & neck SCC cell line SKX, which …

In vivo and in vitro toxicity testing of cyanobacterial toxins: A mini-review

SJ Porzani, ST Lima, JS Metcalf, B Nowruzi - Reviews of Environmental …, 2021 - Springer
Harmful cyanobacterial blooms are increasing and becoming a worldwide concern as many
bloom-forming cyanobacterial species can produce toxic metabolites named cyanotoxins …