The human proteoform project: defining the human proteome
Proteins are the primary effectors of function in biology, and thus, complete knowledge of
their structure and properties is fundamental to deciphering function in basic and …
their structure and properties is fundamental to deciphering function in basic and …
Nanomechanical resonators: toward atomic scale
The quest for realizing and manipulating ever smaller man-made movable structures and
dynamical machines has spurred tremendous endeavors, led to important discoveries, and …
dynamical machines has spurred tremendous endeavors, led to important discoveries, and …
Mesoscopic physics of nanomechanical systems
Nanomechanics has brought mesoscopic physics into the world of vibrations. Because
nanomechanical systems are small, fluctuations are significant, the vibrations already …
nanomechanical systems are small, fluctuations are significant, the vibrations already …
The emerging landscape of single-molecule protein sequencing technologies
Single-cell profiling methods have had a profound impact on the understanding of cellular
heterogeneity. While genomes and transcriptomes can be explored at the single-cell level …
heterogeneity. While genomes and transcriptomes can be explored at the single-cell level …
Resolving heterogeneous macromolecular assemblies by Orbitrap-based single-particle charge detection mass spectrometry
We demonstrate single-particle charge detection mass spectrometry on an Orbitrap for the
analysis of megadalton biomolecular assemblies. We establish that the signal amplitudes of …
analysis of megadalton biomolecular assemblies. We establish that the signal amplitudes of …
Optomechanical detection of vibration modes of a single bacterium
Low-frequency vibration modes of biological particles, such as proteins, viruses and
bacteria, involve coherent collective vibrations at frequencies in the terahertz and gigahertz …
bacteria, involve coherent collective vibrations at frequencies in the terahertz and gigahertz …
The recent progress of MEMS/NEMS resonators
L Wei, X Kuai, Y Bao, J Wei, L Yang, P Song, M Zhang… - Micromachines, 2021 - mdpi.com
MEMS/NEMS resonators are widely studied in biological detection, physical sensing, and
quantum coupling. This paper reviews the latest research progress of MEMS/NEMS …
quantum coupling. This paper reviews the latest research progress of MEMS/NEMS …
Optomechanical mass spectrometry
Nanomechanical mass spectrometry has proven to be well suited for the analysis of high
mass species such as viruses. Still, the use of one-dimensional devices such as vibrating …
mass species such as viruses. Still, the use of one-dimensional devices such as vibrating …
Mass spectrometry-based structural virology
Here we review recent developments in mass spectrometry that have enabled its growing
contribution to the field of structural virology. Evidently, there is a strong renewed general …
contribution to the field of structural virology. Evidently, there is a strong renewed general …
Single virus inductively coupled plasma mass spectroscopy analysis: A comprehensive study
C Degueldre - Talanta, 2021 - Elsevier
The characterisation of individual nanoparticles by single particle ICP-MS (SP-ICP-MS) has
paved the way for the analysis of smallest biological systems. This study suggests to …
paved the way for the analysis of smallest biological systems. This study suggests to …