Functional status is considered the main determinant of healthy aging. Impairment in
skeletal muscle and the cardiovascular system, two interrelated systems, results in …

Background Previous studies have established that diabetes mellitus (DM) markedly raises
the risk of developing erectile dysfunction (ED). Despite extensive investigations, the risk …

Aims Erectile dysfunction is a common complication within many pathological conditions
associated with low testosterone. Testosterone deficiency increases oxidative stress in the …

The impact of aging on vascular function is heterogeneous depending on the vascular
territories. Calcium regulation plays a key role in vascular function and has been implicated …

Background and purpose Alcohol abuse has been associated with erectile dysfunction (ED),
but the implicated molecular mechanisms are unresolved. This study analyses the role of …

Vascular territories display heterogeneous sensitivity to the impacts of aging. The relevance
of the STIM/Orai system to vascular function depends on the vascular bed. We aimed to …

High-fat diets (HFDs) have pervaded modern dietary habits, characterized by their excessive
saturated fat content and low nutritional value. Epidemiological studies have compellingly …

Background With the increasing trend ofpopulation aging, erectile dysfunction (ED) among
elderly men has emerged as apressing health concern. Despite extensive research on the …

Aging-related hypoxia, oxidative stress, and inflammation pathophysiology are closely
associated with human age-related carcinogenesis and chronic diseases. However, the …

尽管医疗卫生技术的进步使心血管疾病死亡率逐年降低, 但心血管事件仍然是导致全球人口寿命
缩短的重要原因, 其中男性患病年龄多早于女性. 识别及减少心血管疾病危险因素 …