Abstract Treatment of high-grade serous ovarian cancer (HGSOC) remains challenging.
Although HGSOC can potentially be responsive to immunotherapy owing to endogenous …

Since our proposal of a dualistic model of epithelial ovarian carcinogenesis more than a
decade ago, a large number of molecular and histopathologic studies were published that …

Unlike other human cancers, in which all primary tumors arise de novo, ovarian epithelial
cancers are primarily imported from either endometrial or fallopian tube epithelium. The …

High-grade serous ovarian cancer, also known as high-grade serous carcinoma (HGSC), is
the most common and deadliest type of ovarian cancer. HGSC appears to arise from the …

The fallopian tube secretory cell is the cell of origin for the majority of ovarian cancers.
Although it remains unclear what triggers neoplastic transformation of these cells, certain …

TP53 mutations are ubiquitous in high‐grade serous ovarian carcinomas (HGSOC), and the
presence of TP53 mutation discriminates between high and low‐grade serous carcinomas …

Many high-grade serous carcinomas (HGSCs) of the pelvis are thought to originate in the
distal portion of the fallopian tube. Serous tubal intra-epithelial carcinoma (STIC) lesions are …

Serous tubal intraepithelial carcinomas (STICs) have been proposed to be the most likely
precursor of ovarian, tubal and 'primary peritoneal'(pelvic) high‐grade serous carcinoma …

Traditionally, it was thought that ovarian high‐grade serous carcinoma arises from the
ovarian surface epithelium and epithelial inclusion glands and that the pathogenesis is de …

A comprehensive pathological report is essential for optimal patient management, cancer
staging and prognostication. In many countries, proforma reports are used but these vary in …