The tumor microenvironment (TME) plays a key role in cancer development and emergence
of drug resistance. TME modulation has recently garnered attention as a potential approach …

The understanding of macrophages and their pathophysiological role has dramatically
changed within the last decades. Macrophages represent a very interesting cell type with …

Dendritic cells (DCs) are crucial mediators of innate and adaptive antitumor immunity,
whereas exogenously and endogenously driven lipid accumulation causes immune …

Elemental sulfur (ES) and sulfur nanoparticles (SNPs) have been widely used as
antibacterial ingredients, especially in dermatological formulations. However, their use in …

Hepatocellular carcinoma (HCC) is a highly malignant, fatal disease with a complex tumor
microenvironment (TME) characterized by severe immunosuppression and malformed …

Abnormal tumor microenvironment (TME) imposes barriers to nanomedicine penetration into
tumors and evolves tumor-supportive nature to provide tumor cell protection, seriously …

Immunotherapy efficacy has been limited by tumor‐associated macrophages (TAMs), which
are the most abundant immune regulatory cells infiltrating around tumor tissues. The …

To date, cancer remains one of the most lethal diseases that threatens public safety. High
concentrations of reactive oxygen species (ROS) can directly induce cell apoptosis and …

Immunotherapy has significantly improved cancer treatment, yet the immunosuppressive
tumor microenvironment (TME) remains a substantial impediment to therapeutic efficacy …

Bioorthogonal reactions provide a powerful tool to manipulate biological processes in their
native environment. However, the transition-metal catalysts (TMCs) for bioorthogonal …