The function of gut microbiota in immune-related neurological disorders: A review

P Sittipo, J Choi, S Lee, YK Lee - Journal of Neuroinflammation, 2022 - Springer
This review provides an overview of the importance of microbiota in the regulation of gut–
brain communication in immune-related neurological disorders. The gastrointestinal (GI) …

Microbiota metabolites in health and disease

JL McCarville, GY Chen, VD Cuevas… - Annual review of …, 2020 - annualreviews.org
Metabolism is one of the strongest drivers of interkingdom interactions—including those
between microorganisms and their multicellular hosts. Traditionally thought to fuel energy …

B cell-derived GABA elicits IL-10+ macrophages to limit anti-tumour immunity

B Zhang, A Vogelzang, M Miyajima, Y Sugiura, Y Wu… - Nature, 2021 - nature.com
Small, soluble metabolites not only are essential intermediates in intracellular biochemical
processes, but can also influence neighbouring cells when released into the extracellular …

Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression

D Huang, Y Wang, JW Thompson, T Yin… - Nature cell …, 2022 - nature.com
Many cancers have an unusual dependence on glutamine. However, most previous studies
have focused on the contribution of glutamine to metabolic building blocks and the energy …

[HTML][HTML] GABA-receptive microglia selectively sculpt developing inhibitory circuits

E Favuzzi, S Huang, GA Saldi, L Binan, LA Ibrahim… - Cell, 2021 - cell.com
Microglia, the resident immune cells of the brain, have emerged as crucial regulators of
synaptic refinement and brain wiring. However, whether the remodeling of distinct synapse …

Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour

AJ Filiano, Y Xu, NJ Tustison, RL Marsh, W Baker… - Nature, 2016 - nature.com
Immune dysfunction is commonly associated with several neurological and mental
disorders. Although the mechanisms by which peripheral immunity may influence neuronal …

Cytokine targets in the brain: impact on neurotransmitters and neurocircuits

AH Miller, E Haroon, CL Raison… - Depression and …, 2013 - Wiley Online Library
Increasing attention has been paid to the role of inflammation in a host of illnesses including
neuropsychiatric disorders such as depression and anxiety. Activation of the inflammatory …

[HTML][HTML] Neurosteroids as regulators of neuroinflammation

C Yilmaz, K Karali, G Fodelianaki, A Gravanis… - Frontiers in …, 2019 - Elsevier
Neuroinflammation is a physiological protective response in the context of infection and
injury. However, neuroinflammation, especially if chronic, may also drive …

Probiotics function mechanistically as delivery vehicles for neuroactive compounds: microbial endocrinology in the design and use of probiotics

M Lyte - Bioessays, 2011 - Wiley Online Library
I hypothesize here that the ability of probiotics to synthesize neuroactive compounds
provides a unifying microbial endocrinology‐based mechanism to explain the hitherto …

Ion channels and transporters in lymphocyte function and immunity

S Feske, EY Skolnik, M Prakriya - Nature Reviews Immunology, 2012 - nature.com
Lymphocyte function is regulated by a network of ion channels and transporters in the
plasma membrane of B and T cells. These proteins modulate the cytoplasmic concentrations …