For centuries, fermented soy foods have been dietary staples in Asia and, now, in response
to consumer demand, they are available throughout the world. Fermentation bestows unique …

Cardiovascular disease (CVD) is the leading cause of death in the world and our approach
to the control and management of CVD mortality is limited. Nattokinase (NK), the most active …

For centuries, people around the world have used fermentation to preserve and enhance the
flavor of a wide variety of foods. Today, complex interactions of microbiota in the digestive …

Accumulation of fibrin in the blood vessels usually results in thrombosis, leading to
myocardial infarction and other cardiovascular diseases. For thrombolytic therapy, microbial …

Bacillus subtilis, belonging to the type species of Bacillus, is a type of soil-derived, low% G+
C, endospore-forming Gram-positive bacterium. After the discovery of B. subtilis 168 that …

Cardiac disorders such as acute myocardial infarction, embolism and stroke are primarily
attributed to excessive fibrin accumulation in the blood vessels, usually consequential in …

Nattokinase (NK), known as a potent fibrinolytic and antithrombotic agent, has been shown
to have antiatherosclerotic and lipid-lowering effects. However, data on human clinical …

Response surface methodology and central composite rotary design (CCRD) was employed
to optimize a fermentation medium for the production of Nattokinase by Bacillus subtilis at …

Thrombosis has threatened human health in past decades. Bacillus nattokinase is a
potential low-cost thrombolytic drug without side-effects and has been introduced into the …

The highly fibrinolytic enzyme-producing bacterium was identified as Bacillus subtilis DC27
and isolated from Douchi, a traditional fermented soybean food. The DFE27 enzyme was …