Nearly all infectious agents contain DNA or RNA genomes, making sequencing an attractive
approach for pathogen detection. The cost of high-throughput or next-generation …

Abstract The recent Ebola and Zika epidemics demonstrate the need for the continuous
surveillance, rapid diagnosis and real-time tracking of emerging infectious diseases. Fast …

The gold standard for clinical diagnosis of bacterial lower respiratory infections (LRIs) is
culture, which has poor sensitivity and is too slow to guide early, targeted antimicrobial …

Agnostic metagenomic next-generation sequencing (mNGS) has emerged as a promising
single, universal pathogen detection method for infectious disease diagnostics. This …

Respiratory microbial dysbiosis is associated with acute respiratory distress syndrome
(ARDS) and hospital-acquired pneumonia (HAP) in critically ill patients. However, we lack …

An increasing number of critically ill patients are immunocompromised. Acute hypoxemic
respiratory failure (ARF), chiefly due to pulmonary infection, is the leading reason for ICU …

Next-generation sequencing (NGS) technologies have become increasingly available for
use in the clinical microbiology diagnostic environment. There are three main applications of …

The massive consumption of antibiotics in the ICU is responsible for substantial ecological
side effects that promote the dissemination of multidrug-resistant bacteria (MDRB) in this …

Pneumonia is a type of acute lower respiratory infection that is common and severe. The
outcome of lower respiratory infection is determined by the degrees to which immunity is …

Background Lower respiratory tract infections (LRTIs) are a leading cause of childhood
morbidity and mortality. Potentially pathogenic organisms are present in the respiratory tract …