New evidence has stirred up a long‐standing but undeservedly forgotten interest in the role
of erythrocytes, or red blood cells (RBCs), in blood clotting and its disorders. This review …

In contrast to an obsolete notion that erythrocytes, or red blood cells (RBC s), play a passive
and minor role in haemostasis and thrombosis, over the past decades there has been …

Red blood cell (RBC) aggregate to form two-and three-dimensional structures when
suspended in aqueous solutions containing large plasma proteins or polymers; this …

Mid-life stage adults are at higher risk of developing venous thrombosis
(VT)/thromboembolism (VT/E). Aging is characterized by an overproduction of reactive …

Sickle cell disease (SCD) is an inherited monogenic disorder and the most common severe
hemoglobinopathy in the world. SCD is characterized by a point mutation in the β-globin …

Thrombosis is a common disorder with a relevant burden of morbidity and mortality
worldwide, particularly among elderly patients. Growing evidence demonstrated a direct role …

Separation of red blood cells and plasma in microcirculatory vessels produces a cell-free
layer at the wall. This layer may be an important determinant of blood viscosity and wall …

This review discusses the cell-free layer at the wall of the microcirculatory vessels with
emphasis on the influence of blood rheological parameters on its formation as well as its …

Since the identification of the elusive endothelium-derived relaxing factor as nitric oxide
(NO), much attention has been devoted to understanding its physiological effects. NO is a …

The cerebral endothelium is an active interface between blood and the central nervous
system. In addition to being a physical barrier between the blood and the brain, the …