Estrogenic endocrine disruptors: Molecular mechanisms of action

R Kiyama, Y Wada-Kiyama - Environment International, 2015 - Elsevier
A comprehensive summary of more than 450 estrogenic chemicals including estrogenic
endocrine disruptors is provided here to understand the complex and profound impact of …

[HTML][HTML] The impact of endocrine-disrupting chemical exposure in the mammalian hypothalamic-pituitary axis

JB Graceli, RS Dettogni, E Merlo, O Nino… - Molecular and Cellular …, 2020 - Elsevier
The hypothalamic-pituitary axis (HP axis) plays a critical and integrative role in the
endocrine system control to maintain homeostasis. The HP axis is responsible for the …

Tributyltin chloride leads to adiposity and impairs metabolic functions in the rat liver and pancreas

BD Bertuloso, PL Podratz, E Merlo, JFP de Araújo… - Toxicology letters, 2015 - Elsevier
Tributyltin chloride (TBT) is an environmental contaminant used in antifouling paints of
boats. Endocrine disruptor effects of TBT are well established in animal models. However …

Evaluation of estrogenic potential of flavonoids using a recombinant yeast strain and MCF7/BUS cell proliferation assay

FA Resende, APS de Oliveira, MS de Camargo… - Plos one, 2013 - journals.plos.org
Phytoestrogens are of interest because of their reported beneficial effects on many human
maladies including cancer, neurodegeneration, cardiovascular disease and diabetes …

Environmental obesogen tributyltin chloride leads to abnormal hypothalamic-pituitary-gonadal axis function by disruption in kisspeptin/leptin signaling in female rats

GC Sena, LC Freitas-Lima, E Merlo, PL Podratz… - Toxicology and Applied …, 2017 - Elsevier
Tributyltin chloride (TBT) is a xenobiotic used as a biocide in antifouling paints that has been
demonstrated to induce endocrine-disrupting effects, such as obesity and reproductive …

Cerebral concentration and toxicity of endocrine disrupting chemicals: The implication of blood-brain interfaces

A Denuzière, JF Ghersi-Egea - NeuroToxicology, 2022 - Elsevier
Endocrine disrupting chemicals (EDCs) act on peripheral endocrine organs or interfere with
general endocrine pathways. Several EDCs alter the central regulation of neuroendocrine …

The roles of triiodothyronine and irisin in improving the lipid profile and directing the browning of human adipose subcutaneous cells

M de Oliveira, LS Mathias, BM Rodrigues… - Molecular and cellular …, 2020 - Elsevier
Abstract Triiodothyronine (T3) and irisin (I) can modulate metabolic status, increase heat
production, and promote differentiation of white adipose tissue (WAT) into brown adipose …

Environmental Health and Toxicology: Immunomodulation Promoted by Endocrine-Disrupting Chemical Tributyltin

RC Da Silva, MP Teixeira, LS de Paiva… - Toxics, 2023 - mdpi.com
Tributyltin (TBT) is an environmental contaminant present on all continents, including
Antarctica, with a potent biocidal action. Its use began to be intensified during the 1960s. It …

Tributyltin and the female hypothalamic-pituitary-gonadal disruption

KL Barbosa, RS Dettogni, CS Da Costa… - Toxicological …, 2022 - academic.oup.com
The hypothalamic-pituitary-gonadal (HPG) axis is the principal modulator of reproductive
function. Proper control of this system relies on several hormonal pathways, which make the …

Tributyltin: advancing the science on assessing endocrine disruption with an unconventional endocrine-disrupting compound

L Lagadic, I Katsiadaki, R Biever, PD Guiney… - … and Toxicology Volume …, 2018 - Springer
Tributyltin (TBT) has been recognized as an endocrine disrupting chemical (EDC) for
several decades. However, only in the last decade, was its primary endocrine mechanism of …