Role of bacterial efflux pumps in antibiotic resistance, virulence, and strategies to discover novel efflux pump inhibitors
The problem of antibiotic resistance among pathogenic bacteria has reached a crisis level.
The treatment options against infections caused by multiple drug-resistant bacteria are …
The treatment options against infections caused by multiple drug-resistant bacteria are …
Physiological functions of bacterial “multidrug” efflux pumps
PJF Henderson, C Maher, LDH Elbourne… - Chemical …, 2021 - ACS Publications
Bacterial multidrug efflux pumps have come to prominence in human and veterinary
pathogenesis because they help bacteria protect themselves against the antimicrobials …
pathogenesis because they help bacteria protect themselves against the antimicrobials …
Cross-protection and cross-feeding between Klebsiella pneumoniae and Acinetobacter baumannii promotes their co-existence
Acinetobacter baumannii and Klebsiella pneumoniae are opportunistic pathogens
frequently co-isolated from polymicrobial infections. The infections where these pathogens …
frequently co-isolated from polymicrobial infections. The infections where these pathogens …
Efflux pump mediated antimicrobial resistance by staphylococci in health-related environments: challenges and the quest for inhibition
A Dashtbani-Roozbehani, MH Brown - Antibiotics, 2021 - mdpi.com
The increasing emergence of antimicrobial resistance in staphylococcal bacteria is a major
health threat worldwide due to significant morbidity and mortality resulting from their …
health threat worldwide due to significant morbidity and mortality resulting from their …
Update on multidrug resistance efflux pumps in Acinetobacter spp
V Kornelsen, A Kumar - Antimicrobial agents and chemotherapy, 2021 - Am Soc Microbiol
Acinetobacter spp. have become of increased clinical importance as studies have shown the
antimicrobial resistant potential of these species. Efflux pumps can lead to reduced …
antimicrobial resistant potential of these species. Efflux pumps can lead to reduced …
The evolutionary conservation of Escherichia coli drug efflux pumps supports physiological functions
T Teelucksingh, LK Thompson, G Cox - Journal of bacteriology, 2020 - Am Soc Microbiol
Bacteria harness an impressive repertoire of resistance mechanisms to evade the inhibitory
action of antibiotics. One such mechanism involves efflux pump-mediated extrusion of drugs …
action of antibiotics. One such mechanism involves efflux pump-mediated extrusion of drugs …
The whole is bigger than the sum of its parts: drug transport in the context of two membranes with active efflux
VV Rybenkov, HI Zgurskaya, C Ganguly… - Chemical …, 2021 - ACS Publications
Cell envelope plays a dual role in the life of bacteria by simultaneously protecting it from a
hostile environment and facilitating access to beneficial molecules. At the heart of this ability …
hostile environment and facilitating access to beneficial molecules. At the heart of this ability …
Assembly and regulation of the chlorhexidine-specific efflux pump AceI
Few antibiotics are effective against Acinetobacter baumannii, one of the most successful
pathogens responsible for hospital-acquired infections. Resistance to chlorhexidine, an …
pathogens responsible for hospital-acquired infections. Resistance to chlorhexidine, an …
Microbial resistance: The role of efflux pump superfamilies and their respective substrates
ÍR Garcia, FA de Oliveira Garcia, PS Pereira… - Life Sciences, 2022 - Elsevier
The microorganism resistance to antibiotics has become one of the most worrying issues for
science due to the difficulties related to clinical treatment and the rapid spread of diseases …
science due to the difficulties related to clinical treatment and the rapid spread of diseases …
The Acinetobacter baumannii disinfectant resistance protein, AmvA, is a spermidine and spermine efflux pump
Antimicrobial resistance genes, including multidrug efflux pumps, evolved long before the
ubiquitous use of antimicrobials in medicine and infection control. Multidrug efflux pumps …
ubiquitous use of antimicrobials in medicine and infection control. Multidrug efflux pumps …