Role of bacterial efflux pumps in antibiotic resistance, virulence, and strategies to discover novel efflux pump inhibitors

A Gaurav, P Bakht, M Saini, S Pandey… - …, 2023 - microbiologyresearch.org
The problem of antibiotic resistance among pathogenic bacteria has reached a crisis level.
The treatment options against infections caused by multiple drug-resistant bacteria are …

Physiological functions of bacterial “multidrug” efflux pumps

PJF Henderson, C Maher, LDH Elbourne… - Chemical …, 2021 - ACS Publications
Bacterial multidrug efflux pumps have come to prominence in human and veterinary
pathogenesis because they help bacteria protect themselves against the antimicrobials …

Cross-protection and cross-feeding between Klebsiella pneumoniae and Acinetobacter baumannii promotes their co-existence

L Semenec, AK Cain, CJ Dawson, Q Liu, H Dinh… - Nature …, 2023 - nature.com
Acinetobacter baumannii and Klebsiella pneumoniae are opportunistic pathogens
frequently co-isolated from polymicrobial infections. The infections where these pathogens …

Efflux pump mediated antimicrobial resistance by staphylococci in health-related environments: challenges and the quest for inhibition

A Dashtbani-Roozbehani, MH Brown - Antibiotics, 2021 - mdpi.com
The increasing emergence of antimicrobial resistance in staphylococcal bacteria is a major
health threat worldwide due to significant morbidity and mortality resulting from their …

Update on multidrug resistance efflux pumps in Acinetobacter spp

V Kornelsen, A Kumar - Antimicrobial agents and chemotherapy, 2021 - Am Soc Microbiol
Acinetobacter spp. have become of increased clinical importance as studies have shown the
antimicrobial resistant potential of these species. Efflux pumps can lead to reduced …

The evolutionary conservation of Escherichia coli drug efflux pumps supports physiological functions

T Teelucksingh, LK Thompson, G Cox - Journal of bacteriology, 2020 - Am Soc Microbiol
Bacteria harness an impressive repertoire of resistance mechanisms to evade the inhibitory
action of antibiotics. One such mechanism involves efflux pump-mediated extrusion of drugs …

The whole is bigger than the sum of its parts: drug transport in the context of two membranes with active efflux

VV Rybenkov, HI Zgurskaya, C Ganguly… - Chemical …, 2021 - ACS Publications
Cell envelope plays a dual role in the life of bacteria by simultaneously protecting it from a
hostile environment and facilitating access to beneficial molecules. At the heart of this ability …

Assembly and regulation of the chlorhexidine-specific efflux pump AceI

JR Bolla, AC Howes, F Fiorentino… - Proceedings of the …, 2020 - National Acad Sciences
Few antibiotics are effective against Acinetobacter baumannii, one of the most successful
pathogens responsible for hospital-acquired infections. Resistance to chlorhexidine, an …

Microbial resistance: The role of efflux pump superfamilies and their respective substrates

ÍR Garcia, FA de Oliveira Garcia, PS Pereira… - Life Sciences, 2022 - Elsevier
The microorganism resistance to antibiotics has become one of the most worrying issues for
science due to the difficulties related to clinical treatment and the rapid spread of diseases …

The Acinetobacter baumannii disinfectant resistance protein, AmvA, is a spermidine and spermine efflux pump

FL Short, Q Liu, B Shah, HE Clift, V Naidu, L Li… - Communications …, 2021 - nature.com
Antimicrobial resistance genes, including multidrug efflux pumps, evolved long before the
ubiquitous use of antimicrobials in medicine and infection control. Multidrug efflux pumps …