Pain modulation in the spinal cord

CJ Woolf - Frontiers in Pain Research, 2022 - frontiersin.org
The sensory inflow from the periphery that triggers innocuous and painful sensations is
highly complex, capturing key elements of the nature of any stimulus, its location, intensity …

Multiscale computer model of the spinal dorsal horn reveals changes in network processing associated with chronic pain

L Medlock, K Sekiguchi, S Hong… - Journal of …, 2022 - Soc Neuroscience
Pain-related sensory input is processed in the spinal dorsal horn (SDH) before being
relayed to the brain. That processing profoundly influences whether stimuli are correctly or …

Ca2+-Permeable AMPA Receptors Contribute to Changed Dorsal Horn Neuronal Firing and Inflammatory Pain

O Kopach, Y Dobropolska, P Belan… - International Journal of …, 2023 - mdpi.com
The dorsal horn (DH) neurons of the spinal cord play a critical role in nociceptive input
integration and processing in the central nervous system. Engaged neuronal classes and …

The use of diffusion tensor imaging in spinal pathology: a comprehensive literature review

T Scullen, J Milburn, K Aria, M Mathkour… - European Spine …, 2024 - Springer
Study design We reviewed the available literature systematically without meta-analysis
following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses …

Modulation of GABAergic synaptic transmission by NMDA receptors in the dorsal horn of the spinal cord

B Leonardon, L Cathenaut… - Frontiers in Molecular …, 2022 - frontiersin.org
The dorsal horn (DH) of the spinal cord is an important structure involved in the integration of
nociceptive messages. Plastic changes in the properties of neuronal networks in the DH …

Upregulation of Spinal MDGA1 in Rats After Nerve Injury Alters Interactions Between Neuroligin-2 and Postsynaptic Scaffolding Proteins and Increases GluR1 Subunit …

HL Li, RJ Guo, ZR Ai, S Han, Y Guan, JF Li… - Neurochemical …, 2024 - Springer
Previous studies suggested that postsynaptic neuroligin-2 may shift from inhibitory toward
excitatory function under pathological pain conditions. We hypothesize that nerve injury may …

[HTML][HTML] Lysophosphatidylcholine induced by fat transplantation regulates hyperalgesia by affecting the dysfunction of ACC perineuronal nets

J Li, Z Li, Y Liu, Y Li, Y Wu, A Manyande, Z Li, H Xiang - iScience, 2024 - cell.com
The pathogenesis of hyperalgesia is complex and can lead to poor clinical treatment. Our
study revealed that epididymal white adipose tissue (eWAT) from spared nerve injury (SNI) …

Short-term plasticity in the spinal nociceptive system

L Cathenaut, R Schlichter, S Hugel - Pain, 2022 - journals.lww.com
Somatosensory information is delivered to neuronal networks of the dorsal horn (DH) of the
spinal cord by the axons of primary afferent neurons that encode the intensity of peripheral …

Effect of different glyphosate doses on the chemical coding of neurons of the enteric nervous system of the porcine descending colon

M Bulc, J Całka, B Jana, K Palus - Folia Morphologica, 2024 - journals.viamedica.pl
Background: Neurons of the enteric nervous system are characterised by high neuronal
plasticity, with their number likely to change in response to various endogenous and …

Réseaux spinaux et transmission nociceptive

S Hugel, P Inquimbert, R Schlichter - Douleur et Analgésie, 2022 - search.proquest.com
L'intégration et la modulation de l'information nociceptive à un stade précoce de son
traitement par le système nerveux central jouent un rôle clé dans l'élaboration de la …