Intracerebroventricular streptozotocin injections as a model of Alzheimer's disease: in search of a relevant mechanism
P Grieb - Molecular neurobiology, 2016 - Springer
Abstract Streptozotocin (STZ), a glucosamine-nitrosourea compound derived from soil
bacteria and originally developed as an anticancer agent, in 1963 has been found to induce …
bacteria and originally developed as an anticancer agent, in 1963 has been found to induce …
The coronaviruses of animals and birds: their zoonosis, vaccines, and models for SARS-CoV and SARS-CoV2
AM Alluwaimi, IH Alshubaith, AM Al-Ali… - Frontiers in veterinary …, 2020 - frontiersin.org
The viruses of the family Coronaviridae are ubiquitous in nature due to their existence in a
wide spectrum of mammals and avian species. The coronaviruses, as RNA viruses, exist as …
wide spectrum of mammals and avian species. The coronaviruses, as RNA viruses, exist as …
Animal models in cardiovascular research: hypertension and atherosclerosis
Hypertension and atherosclerosis are among the most common causes of mortality in both
developed and developing countries. Experimental animal models of hypertension and …
developed and developing countries. Experimental animal models of hypertension and …
Choosing the right animal model for infectious disease research
JR Swearengen - Animal models and experimental medicine, 2018 - Wiley Online Library
A complex biological system is often required to study the myriad of host‐pathogen
interactions associated with infectious diseases, especially since the current basis of biology …
interactions associated with infectious diseases, especially since the current basis of biology …
Strategies for the discovery, identification and validation of milk protein-derived bioactive peptides
AB Nongonierma, RJ FitzGerald - Trends in Food Science & Technology, 2016 - Elsevier
Background The workflow used for the discovery of novel milk protein-derived bioactive
peptides (BAPs) has significantly evolved over the past number of years. Many of the …
peptides (BAPs) has significantly evolved over the past number of years. Many of the …
Preclinical animal models of mental illnesses to translate findings from the bench to the bedside: molecular brain mechanisms and peripheral biomarkers associated …
N Cattane, AC Vernon, A Borsini, C Scassellati… - European …, 2022 - Elsevier
Animal models are useful preclinical tools for studying the pathogenesis of mental disorders
and the effectiveness of their treatment. While it is not possible to mimic all symptoms …
and the effectiveness of their treatment. While it is not possible to mimic all symptoms …
Pigs as a model for biomedical sciences.
KN Kuzmuk, LB Schook - The genetics of the pig, 2011 - cabidigitallibrary.org
The genetics of the pig: Pigs as a model for biomedical sciences. Page 1 ©CAB International
2011. The Genetics of the Pig, 426 2nd Edn (eds MF Rothschild and A. Ruvinsky) Kristy N …
2011. The Genetics of the Pig, 426 2nd Edn (eds MF Rothschild and A. Ruvinsky) Kristy N …
Animal models in pharmacology: A brief history awarding the nobel prizes for physiology or medicine
Abstract Background: The Nobel Prize of Physiology or Medicine (NPPM) has recognized
the work of 222 scientists from different nationalities, from 1901 until 2020. From the total …
the work of 222 scientists from different nationalities, from 1901 until 2020. From the total …
Research Progress on the Construction and Application of a Diabetic Zebrafish Model
Y Cao, Q Chen, Y Liu, L Jin, R Peng - International Journal of Molecular …, 2023 - mdpi.com
Diabetes is a metabolic disease characterized by high blood glucose levels. With economic
development and lifestyle changes, the prevalence of diabetes is increasing yearly. Thus, it …
development and lifestyle changes, the prevalence of diabetes is increasing yearly. Thus, it …
[HTML][HTML] Are some animal models more equal than others? A case study on the translational value of animal models of efficacy for Alzheimer's disease
DH Veening-Griffioen, GS Ferreira… - European journal of …, 2019 - Elsevier
Abstract Clinical trial failures (> 99%) in Alzheimer's disease are in stark contrast to positive
efficacy data in animals. We evaluated the correlation between animal and clinical efficacy …
efficacy data in animals. We evaluated the correlation between animal and clinical efficacy …