Linkage chemistry of S (VI) fluorides

D Zeng, WP Deng, X Jiang - Chemistry–A European Journal, 2023 - Wiley Online Library
Sulfur (VI)‐fluoride exchange linkage as a next generation of click chemistry was introduced
by Sharpless and coworkers in 2014. Distinguished from CuAAC, the SuFEx reaction …

Click chemistry in the design of AIEgens for biosensing and bioimaging

MC Giel, Y Hong - Aggregate, 2023 - Wiley Online Library
The development of rapid, selective, and sensitive fluorescent sensors is essential for
visualizing and quantifying biological molecules and processes in vitro, ex vitro, and in vivo …

Epigenetic analysis of cell-free DNA by fragmentomic profiling

Q Zhou, G Kang, P Jiang, R Qiao… - Proceedings of the …, 2022 - National Acad Sciences
Cell-free DNA (cfDNA) fragmentation patterns contain important molecular information
linked to tissues of origin. We explored the possibility of using fragmentation patterns to …

[HTML][HTML] Phage diversity in cell-free DNA identifies bacterial pathogens in human sepsis cases

NL Haddock, LJ Barkal, N Ram-Mohan, G Kaber… - Nature …, 2023 - nature.com
Bacteriophages, viruses that infect bacteria, have great specificity for their bacterial hosts at
the strain and species level. However, the relationship between the phageome and …

Chronic graft-versus-host disease detected by tissue-specific cell-free DNA methylation biomarkers

B Avni, D Neiman, E Shaked… - The Journal of …, 2024 - Am Soc Clin Investig
BACKGROUND. Accurate detection of graft-versus-host disease (GVHD) is a major
challenge in the management of patients undergoing hematopoietic stem cell …

Ethene‐1, 1‐disulfonyl Difluoride (EDSF) for SuFEx Click Chemistry: Synthesis of SuFExable 1, 1‐Bissulfonylfluoride Substituted Cyclobutene Hubs

CJ Smedley, MC Giel, T Fallon… - Angewandte Chemie …, 2023 - Wiley Online Library
We present the synthesis of 1, 1‐bis (fluorosulfonyl)‐2‐(pyridin‐1‐ium‐1‐yl) ethan‐1‐ide, a
bench‐stable precursor to ethene‐1, 1‐disulfonyl difluoride (EDSF). The novel SuFEx …

Plasma cell-free RNA signatures of inflammatory syndromes in children

CJ Loy, V Servellita, A Sotomayor-Gonzalez… - Proceedings of the …, 2024 - pnas.org
Inflammatory syndromes, including those caused by infection, are a major cause of hospital
admissions among children and are often misdiagnosed because of a lack of advanced …

Biomarkers for early complications post hematopoietic cell transplantation: Insights and challenges

B Balakrishnan, UP Kulkarni, AA Pai… - Frontiers in …, 2023 - frontiersin.org
Hematopoietic cell transplantation is an established curative treatment option for various
hematological malignant, and non-malignant diseases. However, the success of HCT is still …

Modular synthesis of functional libraries by accelerated SuFEx click chemistry

JA Homer, RA Koelln, AS Barrow, TL Gialelis… - Chemical …, 2024 - pubs.rsc.org
Accelerated SuFEx Click Chemistry (ASCC) is a powerful method for coupling aryl and alkyl
alcohols with SuFEx-compatible functional groups. With its hallmark favorable kinetics and …

A hitchhiker's guide to cell-free DNA biology

F Mouliere - Neuro-oncology advances, 2022 - academic.oup.com
Liquid biopsy provides a noninvasive window to the cancer genome and physiology. In
particular, cell-free DNA (cfDNA) is a versatile analyte for guiding treatment, monitoring …