The cyclin-dependent kinase Cdk1 is best known for its function as master regulator of the
cell cycle. It phosphorylates several key proteins to control progression through the different …

Largely non-overlapping sets of cyclin-dependent kinases (CDKs) regulate cell division and
RNA polymerase II (Pol II)-dependent transcription. Here we review the molecular …

The epigenetic phenomenon is known to derive the phenotypic variation of an organism
through an interconnected cellular network of histone modifications, DNA methylation and …

Deubiquitination is an important form of post-translational modification that regulates protein
homeostasis. Ovarian tumor domain-containing proteins (OTUDs) subfamily member …

RNA polymerase II relies on a repetitive sequence domain (YSPTSPS) within its largest
subunit to orchestrate transcription. While phosphorylation on serine-2/serine-5 of the …

The largest subunit of RNA polymerase II (Pol II) has an unusual carboxyl‐terminal domain
(CTD). This domain is composed of a tandemly repeating heptapeptide, Y1S2P3T4S5P6S7 …

Bromodomain protein 4 (BRD4) is a transcriptional and epigenetic regulator that is a
therapeutic target in many cancers and inflammatory diseases. BRD4 plays important roles …

Chronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory disease of the nose
and paranasal sinuses characterized by the presence of nasal polyps. The symptoms …

ABSTRACT RNA polymerase II (Pol II) is composed of 12 subunits that collaborate to
synthesize mRNA within the nucleus. Pol II is widely recognized as a passive holoenzyme …

A family of structurally related cyclin‐dependent protein kinases (CDKs) drives many
aspects of eukaryotic cell function. Much of the literature in this area has considered …