As an image-based single-cell transcriptomics approach, multiplexed error-robust
fluorescence in situ hybridization (MERFISH) allows hundreds to thousands of RNA species …

Combining and multiplexing microscopy approaches is crucial to understand cellular events,
but requires elaborate workflows. Here, we present a robust, open-source approach for …

Neuronal synapses transmit electrochemical signals between cells through the coordinated
action of presynaptic vesicles, ion channels, scaffolding and adapter proteins, and …

Probing the molecular organization of tissues requires in situ analysis by microscopy.
However current limitations in multiplexing, sensitivity, and throughput collectively constitute …

Technologies that visualize multiple biomolecules at the nanometer scale in cells will enable
deeper understanding of biological processes that proceed at the molecular scale. Current …

Integrative and hybrid methods have the potential to bridge long-standing knowledge gaps
in structural biology. These methods will have a prominent role in the future of the field as we …

Objective: Large-scale and automated detection of fluorescent microscopic synaptic images
are essential for the understanding of brain function and disorders at the molecular level …

Neuronal synapses contain hundreds of protein species whose expression levels and sub-
micron-scale localizations are core determinants of neuronal plasticity and signal …

the disclosed invention is generally in the field of nucleic acid assemblies and specifically in
the area of nucleic acid assemblies for targeting cargo to cells, tissues, organs, and …

datasets are generated with antibody or oligonucleotide probes panels in which each
antibody or oligonucleotide is conjugated to a polymer that chelates stable metal isotopes …