Prioritization of immunogenic neoantigens is key to enhancing cancer immunotherapy
through the development of personalized vaccines, adoptive T cell therapy, and the …

Background: Cancer is the major public health problem in developing countries. The
treatment of cancer requires a multimodal approach and chemotherapy is one of them …

T-cell specificity to differentiate between self and non-self relies on T-cell receptor (TCR)
recognition of peptides presented by the Major Histocompatibility Complex (MHC) …

Hydrophobic neoantigens are more immunogenic because they are better presented by the
major histocompatibility complex and better recognized by T cells. Tumor cells can evade …

Recent structural characterizations of classical and non‐classical major histocompatibility
complex class II (MHCII) proteins have provided a view into the dynamic nature of the MHCII …

HLA-DM mediates the exchange of peptides loaded onto MHCII molecules during antigen
presentation by a mechanism that remains unclear and controversial. Here, we investigated …

Bovine leukemia virus (BLV) infections, causing persistent lymphocytosis and lethal
lymphosarcoma in cattle, have reached high endemicity on dairy farms. We observed …

Ligand binding is a thermodynamically cooperative process in many biochemical systems
characterized by the conformational flexibility of the reactants. However, the contribution of …

Vaccination clearly decreases coronavirus disease 2019 (COVID-19) mortality; however,
they also impose selection pressure on the virus, which promotes the evolution of immune …

Mycobacterium avium subspecies paratuberculosis (MAP) is a global concern in modern
livestock production worldwide. The available vaccines against paratuberculosis do not offer …