This Review is intended to help clinicians, patients, and the public make informed decisions
about statin therapy for the prevention of heart attacks and strokes. It explains how the …

Statins inhibit the critical step of cholesterol synthesis in which 3-hydroxy-3-methylglutaryl
coenzyme A (HMGC) is transformed to mevalonate by the enzyme HMGC reductase. By …

Importance For patients with limited prognosis, some medication risks may outweigh the
benefits, particularly when benefits take years to accrue; statins are one example. Data are …

Aims The role of statin therapy in primary prevention of cardiovascular disease in persons
older than 75 years remains a subject of debate with little evidence to support or exclude the …

A review of statins for primary prevention of cardiovascular disease could alter guidance for
those with a 10 year risk of less than 10%. John Abramson and colleagues argue that statins …

Background Efficacy of statins has been extensively studied, with much less information
reported on their unintended effects. Evidence from randomized controlled trials (RCTs) on …

Abstract The Proceedings of a Canadian Working Group Consensus Conference, first
published in 2011, provided a summary of statin-associated adverse effects and intolerance …

Importance Cataracts are a main cause of low vision; with the growing elderly population,
the incidence of cataracts is likely to increase. Investigators have previously hypothesized …

Background Statins are widely prescribed for the primary prevention of cardiovascular
disease. Guidelines exist for statin prescriptions, but there is little recent analysis concerning …

Introduction Previous research has shown that statin adherence for the primary prevention of
CVD is lower compared to secondary prevention populations. Therefore the aim of this …