The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …

The placenta is a transient fetal organ that plays a critical role in the health and wellbeing of
both the fetus and its mother. Functionally, the placenta sustains the growth of the fetus as it …

Alzheimer's disease (AD) is characterized by synaptic loss, which can result from
dysfunctional microglial phagocytosis and complement activation. However, what signals …

Osteopontin (OPN) also known by its official gene designation secreted phosphoprotein‐1
(SPP1) is a fascinating, multifunctional protein expressed in a number of cell types that …

Adipose tissue constitutes an extremely active endocrine organ with a network of signaling
pathways enabling the organism to adapt to a wide range of different metabolic challenges …

Since its first description more than 20 years ago osteopontin has emerged as an active
player in many physiological and pathological processes, including biomineralization, tissue …

Innate immune responses combat infectious microorganisms by inducing inflammatory
responses, antimicrobial pathways and adaptive immunity. Multiple genes within each of …

Osteopontin (OPN) is a matricellular protein that mediates diverse biological functions. OPN
is involved in normal physiological processes and is implicated in the pathogenesis of a …

The glycoprotein osteopontin (OPN) possesses multiple functions in health and disease. To
this end, osteopontin has beneficial roles in wound healing, bone homeostasis, and …

Recent research has led to a better but as yet incomplete understanding of the complex
roles osteopontin plays in mammalian physiology. A soluble protein found in all body fluids …