An empirical review on the resistance mechanisms of epidermal growth factor receptor inhibitors and predictive molecular biomarkers in colorectal cancer

S Bhattacharya - Critical Reviews in Oncology/Hematology, 2023 - Elsevier
Despite advances in cytotoxic treatments, colorectal cancer remains a leading cause of
death. Metastatic colorectal cancer (mCRC) patients have a poor prognosis despite …

Identification of anoikis-related subgroups and prognosis model in liver hepatocellular carcinoma

Y Chen, W Huang, J Ouyang, J Wang, Z Xie - International journal of …, 2023 - mdpi.com
Resistance to anoikis is a key characteristic of many cancer cells, promoting cell survival.
However, the mechanism of anoikis in hepatocellular carcinoma (HCC) remains unknown …

[HTML][HTML] WNT/β-catenin signaling in hepatocellular carcinoma: The aberrant activation, pathogenic roles, and therapeutic opportunities

A Gajos-Michniewicz, M Czyz - Genes & Diseases, 2024 - Elsevier
Hepatocellular carcinoma (HCC) is a liver cancer, highly heterogeneous both at the
histopathological and molecular levels. It arises from hepatocytes as the result of the …

[HTML][HTML] PPIH gene regulation system and its prognostic significance in hepatocellular carcinoma: a comprehensive analysis

J Ye, Y Pang, X Yang, C Zhang, L Shi, Z Chen… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
Background: Peptidyl-prolyl isomerase H (PPIH) is a member of the cyclophilin protein
family, which functions as a molecular chaperone and is involved in the splicing of pre …

Liver-specific deletion of miR-181ab1 reduces liver tumour progression via upregulation of CBX7

J Chen, Y Zhao, F Zhang, J Li, JA Boland… - Cellular and Molecular …, 2022 - Springer
MiR-181 expression levels increased in hepatocellular carcinoma (HCC) compared to non-
cancerous tissues. MiR-181 has been widely reported as a possible driver of …

[HTML][HTML] The Wnt signaling pathway in hepatocellular carcinoma: Regulatory mechanisms and therapeutic prospects

S Ma, G Meng, T Liu, J You, R He, X Zhao… - Biomedicine & …, 2024 - Elsevier
Hepatocellular carcinoma (HCC) is a malignant tumor that arises from hepatocytes. Multiple
signaling pathways play a regulatory role in the occurrence and development of HCC, with …

Custom gene expression panel for evaluation of potential molecular markers in hepatocellular carcinoma

SR Pallerla, NX Hoan, S Rachakonda, CG Meyer… - BMC Medical …, 2022 - Springer
Background Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related
mortality worldwide. It is a highly heterogeneous disease with poor prognosis and limited …

Bioactive xanthones, benzophenones and biphenyls from mangosteen root with potential anti-migration against hepatocellular carcinoma cells

S Choodej, K Koopklang, A Raksat, N Chuaypen… - Scientific Reports, 2022 - nature.com
Liver cancer refers primarily to hepatocellular carcinoma (HCC) accounting for over 90% of
cases and is the highest incidence in men in Thailand. Over the past decades, the incidence …

Autoantibodies to PAX5, PTCH1, and GNA11 as Serological Biomarkers in the Detection of Hepatocellular Carcinoma in Hispanic Americans

C Qiu, Y Ma, B Wang, X Zhang, X Wang… - International Journal of …, 2023 - mdpi.com
Studies have demonstrated that autoantibodies to tumor-associated antigens (TAAs) may be
used as efficient biomarkers with low-cost and highly sensitive characteristics. In this study …

Generalizable transcriptome-based tumor malignant level evaluation and molecular subtyping towards precision oncology

D Hu, Z Zhang, X Liu, Y Wu, Y An, W Wang… - Journal of Translational …, 2024 - Springer
In cancer treatment, therapeutic strategies that integrate tumor-specific characteristics (ie,
precision oncology) are widely implemented to provide clinical benefits for cancer patients …