Standard treatment of primary and metastatic brain tumours includes high-dose
megavoltage-range radiation to the cranial vault. About half of patients survive> 6 months …

Approximately 100,000 primary and metastatic brain tumor patients/year in the US survive
long enough (> 6 months) to experience radiation-induced brain injury. Prior to 1970, the …

Aim To evaluate the impact of ultra-rapid FLASH mouse whole brain irradiation on
hippocampal dendritic spines and neuroinflammation, factors associated with cognitive …

Radiation-induced late brain injury consisting of vascular abnormalities, demyelination,
white matter necrosis, and cognitive impairment has been described in patients subjected to …

Radiation is an important component of cancer treatment with more than half of all patients
receive radiotherapy during their cancer experience. While the impact of radiation on tumour …

Microglia, which contribute substantially to the tumor mass of glioblastoma, have been
shown to play an important role in glioma growth and invasion. While a large number of …

Abstract Each year, approximately 200,000 patients in the United States will receive partial-
or whole-brain irradiation for the treatment of primary or metastatic brain cancer. Early and …

Approximately 100 000 patients per year in the United States with primary and metastatic
brain tumor survive long enough (> 6 months) to develop radiation-induced brain injury …

Radiation therapy is the most effective non-surgical treatment of primary brain tumors and
metastases. Preclinical studies have provided valuable insights into pathogenesis of …

Little progress has been made in the long-term management of glioblastoma multiforme
(GBM), considered among the most lethal of brain cancers. Cytotoxic chemotherapy …