Ethnopharmacological relevance Catharanthus roseus (L.) G. Don is a well known
medicinal plant belonging to family Apocynaceae that have been traditionally used as …

Astrocytes, the most abundant glial cell types in the brain, provide metabolic and trophic
support to neurons and modulate synaptic activity. Accordingly, impairment in these …

Vinpocetine, a derivative of the alkaloid vincamine, has been clinically used in many
countries for treatment of cerebrovascular disorders such as stroke and dementia for more …

Solute transport through the bone lacunar-canalicular system is believed to be essential for
osteocyte survival and function but has proved difficult to measure. We report an approach …

Although the mechanisms of neurodegeneration in Parkinson's disease are not fully
understood, mitochondrial dysfunction, oxidative stress and environmental toxins may be …

Aims The study aim was to test the efficacy of a novel created hybrid nanosystem compared
to other nanosystems in treatment of scopolamine induced memory impairment. Main …

Multiple genetic, metabolic, and environmental abnormalities are known to contribute to the
pathogenesis of Alzheimer's dementia (AD). If all of those abnormalities were addressed it …

The Apocynaceae plant family contains a great number of so called eburnamine–vincamine
alkaloids. Quite a few of these alkaloids exert varied pharmacological activities on the cell …

Mitochondrial dysfunction including decrease of mitochondrial membrane potential and
reduced ATP production represents a common final pathway of many conditions associated …

In this study, we investigated the effects of the memory-enhancing drugs piracetam,
vincamine, and vinpocetine or the cholinesterase inhibitor donepezil on the development of …