The ability of chemical modifications of single nucleotides to alter the electrostatic charge,
hydrophobic surface and base pairing of RNA molecules is exploited for the clinical use of …

The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …

Among RNA modifications, transfer of methylgroups from the typical cofactor S‐adenosyl‐l‐
methionine by methyltransferases (MTases) to RNA is by far the most common reaction …

To date, more than 90 modified nucleosides have been found in tRNA and the biosynthetic
pathways of the majority of tRNA modifications include a methylation step (s). Recent studies …

We have generated a high-confidence mitochondrial proteome (MitoTag) of the
Trypanosoma brucei procyclic stage containing 1,239 proteins. For 337 of these, a …

Transfer RNAs (tRNAs) are key adaptor molecules of the genetic code that are heavily
modified post-transcriptionally. Inosine at the first residue of the anticodon (position 34; I34) …

The importance of mitochondria for a typical aerobic eukaryotic cell is undeniable, as the list
of necessary mitochondrial processes is steadily growing. Here, we summarize the current …

Deficiencies in respiratory-chain complexes lead to a variety of clinical phenotypes resulting
from inadequate energy production by the mitochondrial oxidative phosphorylation system …

tRNA molecules undergo extensive post-transcriptional processing to generate the mature
functional tRNA species that are essential for translation in all organisms. These processing …

Accurate quantification of the copy numbers of noncoding RNA has recently emerged as an
urgent problem, with impact on fields such as RNA modification research, tissue …