Osteosarcoma is the most common primary malignant bone tumor and is associated with a
high risk of recurrence and distant metastasis. Effective treatment for osteosarcoma …

Osteosarcoma is the most common primary bone cancer in children and young adults.
Limited progress has been made in improving the survival outcomes in patients with …

Cancers arising from germline DNA mismatch repair deficiency or polymerase proofreading
deficiency (MMRD and PPD) in children harbour the highest mutational and microsatellite …

Background Pembrolizumab is approved for the treatment of advanced cancer in adults;
however, no information is available on safety and efficacy in paediatric patients. We aimed …

B-cell lymphoma is a group of hematological malignancies with high clinical and biological
heterogeneity. The pathogenesis of B-cell lymphoma involves a complex interaction …

Purpose: Patients with relapsed pediatric solid malignancies have few therapeutic options,
and many of these patients die of their disease. B7-H3 is an immune checkpoint protein …

Although significant improvements have been made in the outcomes of children with cancer,
the pace of improvement has slowed in recent years as the limits of therapy intensification …

Macrophages are versatile immune cells and can adapt to both external stimuli and their
surrounding environment. Macrophages are categorized into two major categories; M1 …

Aim To evaluate the activity and safety of the PD-1 antibody pembrolizumab in adult patients
with advanced osteosarcoma. Material and methods The study was a single-arm, open …

Purpose: In many cancers, nivolumab in combination with ipilimumab improves response
rates compared with either agent alone, but the combination has not been evaluated in …