Obesity and COVID-19: molecular mechanisms linking both pandemics

A Ritter, NN Kreis, F Louwen, J Yuan - International journal of molecular …, 2020 - mdpi.com
The coronavirus disease 2019 COVID-19 pandemic is rapidly spreading worldwide and is
becoming a major public health crisis. Increasing evidence demonstrates a strong …

The therapeutic potential of apelin in kidney disease

FA Chapman, D Nyimanu, JJ Maguire… - Nature Reviews …, 2021 - nature.com
Chronic kidney disease (CKD) is a leading cause of global morbidity and mortality and is
independently associated with cardiovascular disease. The mainstay of treatment for CKD is …

[HTML][HTML] Exerkines and long-term synaptic potentiation: Mechanisms of exercise-induced neuroplasticity

WAJ Vints, O Levin, H Fujiyama, J Verbunt… - Frontiers in …, 2022 - Elsevier
Physical exercise may improve cognitive function by modulating molecular and cellular
mechanisms within the brain. We propose that the facilitation of long-term synaptic …

The apelin receptor: physiology, pathology, cell signalling, and ligand modulation of a peptide-activated class A GPCR

NA Chapman, DJ Dupré… - Biochemistry and cell …, 2014 - cdnsciencepub.com
The apelin receptor (AR or APJ) is a class A (rhodopsin-like) G-protein-coupled receptor
with wide distribution throughout the human body. Activation of the AR by its cognate …

Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system

P Yang, JJ Maguire, AP Davenport - Trends in pharmacological sciences, 2015 - cell.com
Apelin and its G protein-coupled receptor (GPCR) have emerged as a key signalling
pathway in the cardiovascular system. The peptide is a potent inotropic agent and …

[HTML][HTML] Induced dysregulation of ACE2 by SARS-CoV-2 plays a key role in COVID-19 severity

ME Mehrabadi, R Hemmati, A Tashakor… - Biomedicine & …, 2021 - Elsevier
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the cause of COVID-19, is
reported to increase the rate of mortality worldwide. COVID-19 is associated with acute …

Neuroprotective roles of Apelin-13 in neurological diseases

Y Zhang, W Jiang, W Sun, W Guo, B Xia, X Shen… - Neurochemical …, 2023 - Springer
Apelin is a natural ligand for the G protein-coupled receptor APJ, and the apelin/APJ system
is widely distributed in vivo. Among the apelin family, apelin-13 is the major apelin isoform in …

[HTML][HTML] Apelinergic system structure and function

K Shin, C Kenward, JK Rainey - Comprehensive Physiology, 2017 - ncbi.nlm.nih.gov
Apelin and apela (ELABELA/ELA/Toddler) are two peptide ligands for a class A G-protein-
coupled receptor named the apelin receptor (AR/APJ/APLNR). Ligand-AR interactions have …

Apelin pathway in cardiovascular, kidney, and metabolic diseases: Therapeutic role of apelin analogs and apelin receptor agonists

AA de Oliveira, A Vergara, X Wang, JC Vederas… - Peptides, 2022 - Elsevier
The apelin/apelin receptor (ApelinR) signal transduction pathway exerts essential biological
roles, particularly in the cardiovascular system. Disturbances in the apelin/ApelinR axis are …

[HTML][HTML] Therapeutic potential of apelin and Elabela in cardiovascular disease

S Gao, H Chen - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Abstract Apelin and Elabela (Ela) are peptides encoded by APLN and APELA, respectively,
which act on their receptor APJ and play crucial roles in the body. Recent research has …