Anatomy and function of ventral tegmental area glutamate neurons

J Cai, Q Tong - Frontiers in neural circuits, 2022 - frontiersin.org
The ventral tegmental area (VTA) is well known for regulating reward consumption, learning,
memory, and addiction behaviors through mediating dopamine (DA) release in downstream …

A selected review of recent advances in the study of neuronal circuits using fiber photometry

Y Wang, EM DeMarco, LS Witzel… - … Biochemistry and Behavior, 2021 - Elsevier
To understand the correlation between animal behaviors and the underlying neuronal
circuits, it is important to monitor and record neurotransmission in the brain of freely moving …

VTA glutamate neuron activity drives positive reinforcement absent dopamine co-release

V Zell, T Steinkellner, NG Hollon, SM Warlow, E Souter… - Neuron, 2020 - cell.com
Like ventral tegmental area (VTA) dopamine (DA) neurons, VTA glutamate neuron activity
can support positive reinforcement. However, a subset of VTA neurons co-release DA and …

D1 receptor-expressing neurons in ventral tegmental area alleviate mouse anxiety-like behaviors via glutamatergic projection to lateral septum

Q Tong, X Cui, H Xu, X Zhang, S Hu, F Huang… - Molecular …, 2023 - nature.com
Dopamine (DA) acts as a key regulator in controlling emotion, and dysfunction of DA signal
has been implicated in the pathophysiology of some psychiatric disorders, including anxiety …

Spatial distribution of neurons expressing single, double, and triple molecular characteristics of glutamatergic, dopaminergic, or GABAergic neurons in the mouse …

S Ma, H Zhong, X Liu, L Wang - Journal of Molecular Neuroscience, 2023 - Springer
The ventral tegmental area (VTA) is a heterogeneous midbrain area that plays a significant
role in diverse neural processes such as reward, aversion, and motivation. The VTA …

Mesoaccumbal glutamate neurons drive reward via glutamate release but aversion via dopamine co-release

SM Warlow, SM Singhal, NG Hollon, L Faget… - Neuron, 2024 - cell.com
Ventral tegmental area (VTA) projections to the nucleus accumbens (NAc) drive reward-
related motivation. Although dopamine neurons are predominant, a substantial …

Glutamic acid promotes hair growth in mice

CP Jara, B de Andrade Berti, NF Mendes, DF Engel… - Scientific reports, 2021 - nature.com
Glutamic acid is the main excitatory neurotransmitter acting both in the brain and in
peripheral tissues. Abnormal distribution of glutamic acid receptors occurs in skin …

Converging circuits between pain and depression: the ventral tegmental area as a therapeutic hub

M Flores-García, A Rizzo, MZ Garçon-Poca… - Frontiers in …, 2023 - frontiersin.org
Chronic pain and depression are highly prevalent pathologies and cause a major
socioeconomic burden to society. Chronic pain affects the emotional state of the individuals …

Heterogeneous expression of dopaminergic markers and Vglut2 in mouse mesodiencephalic dopaminergic nuclei A8–A13

M Fougère, CI van der Zouwen… - Journal of …, 2021 - Wiley Online Library
Co‐transmission of glutamate by brain dopaminergic (DA) neurons was recently proposed
as a potential factor influencing cell survival in models of Parkinson's disease. Intriguingly …

VTA multifaceted modulation of CA1 local circuits

T Adeyelu, OM Ogundele - Neurobiology of learning and memory, 2023 - Elsevier
Excitatory pyramidal (PYR) cell activation of interneurons (INT) produces network
oscillations that underlie cognitive processes in the hippocampus (CA1). Neural projections …