Intestinal permeability is a key feature of intestinal barrier function. Altered intestinal
permeability is described in many chronic diseases and may be a risk factor for disease …

Levels of inflammatory mediators in circulation are known to increase with age, but the
underlying cause of this age-associated inflammation is debated. We find that, when …

The intestinal barrier encompasses structural, permeability and immune aspects of the gut
mucosa that, when disrupted, may contribute to chronic inflammation. Although gnotobiotic …

The intestinal epithelium is a highly dynamic structure that rejuvenates in response to acute
stressors and can undergo alterations in cellular composition as animals age. The …

Key points Maternal obesity has been associated with shifts in intestinal microbiota, which
may contribute to impaired barrier function Impaired barrier function may expose the …

The studies described here provide an analysis of the pathogenesis of Blau syndrome and
thereby the function of NOD2 as seen through the lens of its dysfunction resulting from Blau …

Background: A growing body of evidence has linked mental health outcomes to the gut
microbiome. This has led to the investigation of the GI tract as a target for novel treatments …

Systemic inflammation is known to alter behaviour, and since it has been reported that
individuals with autism spectrum disorder (ASD) have higher levels of circulating cytokines …

Aging is accompanied by changes in hematopoiesis and consequently in leukocyte
phenotype and function. Although age-related changes in bone marrow hematopoiesis are …

Introduction: Intestinal flora and the translocation of its products, such as muramyl dipeptide
(MDP), are common causes of sepsis. MDP is a common activator of the intracellular pattern …