The discovery in 2006 that loss-of-function mutations in the filaggrin gene (FLG) cause
ichthyosis vulgaris and can predispose to atopic dermatitis (AD) galvanized the dermatology …

There is a growing desire to explain the worldwide rise in the prevalence of atopic dermatitis
(AD). Trend data on the burden of AD suggest that the picture in the developing world may …

Background The influence of early exposure to allergenic foods on the subsequent
development of food allergy remains uncertain. Objective We sought to determine the …

Background Filaggrin is an epidermal protein that has a role in skin barrier function.
Filaggrin loss-of-function (FLG-LOF) mutations are a significant risk factor for eczema and …

Atopic dermatitis (AD) prevalence is rising worldwide. Literature data suggest the incidence
of AD in developing countries is gradually getting close to that of developed ones, in which …

Food allergy (FA), a growing public health burden in the United States, and familial
aggregation studies support strong roles for both genes and environment in FA risk …

By the late 1980s, it was clear that allergic diseases, including asthma, eczema, allergic
rhinitis and food allergy, had been increasing in recent decades, but the extent of this …

Background Diet diversity (DD) during infancy may prevent food allergies (FA), possibly by
exposing the gastrointestinal microbiota to diverse foods and nutrients. Objective To …

Background Filaggrin (FLG) mutations are major genetic determinants for eczema, but their
role in eczema severity needs further investigation. Children with eczema are at higher risk …

Background Loss‐of‐function variants within the filaggrin gene (FLG) are associated with a
dysfunctional skin barrier that contributes to the development of eczema. Epigenetic …