Bromodomains (BRDs) are evolutionarily conserved protein–protein interaction modules
that are found in a wide range of proteins with diverse catalytic and scaffolding functions and …

Tumour-specific antigens have been an area of interest in cancer therapy since their
discovery in the middle of the 20th century. In the era of immune-based cancer therapeutics …

Fluorescent proteins (FP) are frequently used for studying proteins inside cells. In advanced
fluorescence microscopy, FPs can report on additional intracellular variables. One variable …

Prostate cancer is heterogeneous and patients would benefit from methods that stratify those
who are likely to respond to systemic therapy. Here, we employ single-cell assays for …

INTRODUCTION Tumor analyses have shown that DNA mutations can transform cells in
some situations but not in others. In melanoma, BRAFV600E [serine/threonine-protein …

Global changes in chromatin accessibility may drive cancer progression by reprogramming
transcription factor (TF) binding. In addition, histone acetylation readers such as …

Pluripotent embryonic stem cells (ESCs) are considered to have open and accessible
chromatin relative to differentiated cells. However, as many studies supporting these …

Summary Analysis of The Cancer Genome Atlas and other published data of head and neck
squamous cell carcinoma (HNSCC) reveals somatic alterations of the Hippo-YAP pathway …

Abstract ATPases Associated with Diverse Cellular Activity (AAA ATPase) are essential
enzymes found in all organisms. They are involved in various processes such as DNA …

Despite their indisputable importance in neuroblastoma (NB) pathology, knowledge of the
bases of NB plasticity and heterogeneity remains incomplete. They may be rooted in …