▪ Abstract The compartmentation of eukaryotic cells requires all nuclear proteins to be
imported from the cytoplasm, whereas, for example, transfer RNAs, messenger RNAs, and …

SUMMARY A defining characteristic of eukaryotic cells is the possession of a nuclear
envelope. Transport of macromolecules between the nuclear and cytoplasmic compartments …

An understanding of how the nuclear pore complex (NPC) mediates nucleocytoplasmic
exchange requires a comprehensive inventory of the molecular components of the NPC and …

The mechanism of facilitated translocation through nuclear pore complexes (NPCs) is only
poorly understood. Here, we present a kinetic analysis of the process using various model …

In eukaryotic cells, the enclosure of the genetic information in the nucleus allows the spatial
and temporal separation of DNA replication and transcription from cytoplasmic protein …

The last steps in mRNA export and remodeling are performed by the Nup82 complex, a
large conserved assembly at the cytoplasmic face of the nuclear pore complex (NPC). By …

The nuclear pore complex (NPC) is the sole gateway between the nucleus and the
cytoplasm. NPCs fuse the inner and outer nuclear membranes to form aqueous …

Human TAP is an orthologue of the yeast mRNA export factor Mex67p. In mammalian cells,
TAP has a preferential intranuclear localization, but can also be detected at the nuclear …

Nuclear pore complexes (NPCs) are large proteinaceous assemblies that provide the only
known portals for exchanging macromolecules between the nucleus and cytoplasm. This …

Inclusion body myopathy associated with Paget's disease of bone and frontotemporal
dementia (IBMPFD) is a dominantly inherited degenerative disorder caused by mutations in …