Zebrafish (Danio rerio) is a valuable non-mammalian vertebrate model widely used to study
development and disease, including more recently cancer. The evolutionary conservation of …

Hematopoiesis is a complex process with a variety of different signaling pathways
influencing every step of blood cell formation from the earliest precursors to final …

Hematopoietic stem cells (HSCs) produce all lineages of mature blood cells for the lifetime
of an organism. In vertebrates, HSCs derive from the transition of the hemogenic …

Zebrafish possess a highly developed immune system that is remarkably similar to the
human one. Therefore, it is expected that the majority of the signalling pathways and …

Personalized medicine holds tremendous promise for improving safety and efficacy of drug
therapies by optimizing treatment regimens. Rapidly developed patient-derived xenografts …

The immediate and natural reaction to both infectious challenges and sterile insults
(wounds, tissue trauma or crystal deposition) is an acute inflammatory response. This …

JAK3 is principally activated by members of the interleukin-2 receptor family and plays an
essential role in lymphoid development, with inactivating JAK3 mutations causing autosomal …

Cancer predisposition syndromes are rare, typically monogenic disorders that result from
germline mutations that increase the likelihood of developing cancer. Although these …

Acute myeloid leukemia (AML) is one of the most frequent, complex, and heterogeneous
hematological malignancies. AML prognosis largely depends on acquired cytogenetic …

Purpose Curcumin (CUR) and piperine (PP) are bioactive compounds with prominent
pharmacological activities that have been investigated for the treatment of various diseases …