APT‐weighted MRI: techniques, current neuro applications, and challenging issues

J Zhou, HY Heo, L Knutsson… - Journal of Magnetic …, 2019 - Wiley Online Library
Amide proton transfer‐weighted (APTw) imaging is a molecular MRI technique that
generates image contrast based predominantly on the amide protons in mobile cellular …

An overview of CEST MRI for non-MR physicists

B Wu, G Warnock, M Zaiss, C Lin, M Chen, Z Zhou… - EJNMMI physics, 2016 - Springer
The search for novel image contrasts has been a major driving force in the magnetic
resonance (MR) research community, in order to gain further information on the body's …

Chemical exchange saturation transfer (CEST) and MR Z-spectroscopy in vivo: a review of theoretical approaches and methods

M Zaiss, P Bachert - Physics in Medicine & Biology, 2013 - iopscience.iop.org
Chemical exchange saturation transfer (CEST) of metabolite protons that undergo exchange
processes with the abundant water pool enables a specific contrast for magnetic resonance …

Inverse Z‐spectrum analysis for spillover‐, MT‐, and T1‐corrected steady‐state pulsed CEST‐MRI – application to pH‐weighted MRI of acute stroke

M Zaiss, J Xu, S Goerke, IS Khan, RJ Singer… - NMR in …, 2014 - Wiley Online Library
Endogenous chemical exchange saturation transfer (CEST) effects are always diluted by
competing effects, such as direct water proton saturation (spillover) and semi‐solid …

Correction of B1‐inhomogeneities for relaxation‐compensated CEST imaging at 7 T

J Windschuh, M Zaiss, JE Meissner… - NMR in …, 2015 - Wiley Online Library
Chemical exchange saturation transfer (CEST) imaging of endogenous agents in vivo is
influenced by direct water proton saturation (spillover) and semi‐solid macromolecular …

Identifying recurrent malignant glioma after treatment using amide proton transfer-weighted MR imaging: a validation study with image-guided stereotactic biopsy

S Jiang, CG Eberhart, M Lim, HY Heo, Y Zhang… - Clinical Cancer …, 2019 - AACR
Purpose: To quantify the accuracy of amide proton transfer-weighted (APTw) MRI for
identifying active glioma after treatment via radiographically guided stereotactic tissue …

Applying amide proton transfer‐weighted MRI to distinguish pseudoprogression from true progression in malignant gliomas

BO Ma, JO Blakeley, X Hong, H Zhang… - Journal of Magnetic …, 2016 - Wiley Online Library
Purpose To assess amide proton transfer‐weighted (APTW) imaging features in patients
with malignant gliomas after chemoradiation and the diagnostic performance of APT …

Predicting IDH mutation status in grade II gliomas using amide proton transfer‐weighted (APTw) MRI

S Jiang, T Zou, CG Eberhart… - Magnetic resonance …, 2017 - Wiley Online Library
Purpose To assess the amide proton transfer‐weighted (APTw) MRI features of isocitrate
dehydrogenase (IDH)‐wildtype and IDH‐mutant grade II gliomas and to test the hypothesis …

Review and consensus recommendations on clinical APT‐weighted imaging approaches at 3T: application to brain tumors

J Zhou, M Zaiss, L Knutsson, PZ Sun… - Magnetic resonance …, 2022 - Wiley Online Library
Amide proton transfer‐weighted (APTw) MR imaging shows promise as a biomarker of brain
tumor status. Currently used APTw MRI pulse sequences and protocols vary substantially …

Quantitative assessment of amide proton transfer (APT) and nuclear overhauser enhancement (NOE) imaging with extrapolated semisolid magnetization transfer …

HY Heo, Y Zhang, S Jiang, DH Lee… - Magnetic resonance in …, 2016 - Wiley Online Library
Purpose To evaluate the use of three extrapolated semisolid magnetization transfer
reference (EMR) methods to quantify amide proton transfer (APT) and nuclear Overhauser …