Hepatocytes are the main workers in the hepatic factory, managing metabolism of nutrients
and xenobiotics, production and recycling of proteins, and glucose and lipid homeostasis …

Adrenal glucocorticoids are major modulators of multiple functions, including energy
metabolism, stress responses, immunity, and cognition. The endogenous secretion of …

We take for granted the ability to fall asleep or to snap out of sleep into wakefulness, but
these changes in behavioral state require specific switching mechanisms in the brain that …

Most organisms display endogenously produced∼ 24-hour fluctuations in physiology and
behavior, termed circadian rhythms. Circadian rhythms are driven by a transcriptional …

Time in the biological sense is measured by cycles that range from milliseconds to years.
Circadian rhythms, which measure time on a scale of 24 h, are generated by one of the most …

Astrocytes are active partners in neural information processing [1, 2]. However, the roles of
astrocytes in regulating behavior remain unclear [3, 4]. Because astrocytes have persistent …

A series of findings over the past decade has begun to identify the brain circuitry and
neurotransmitters that regulate our daily cycles of sleep and wakefulness. The latter …

Life is a cyclical chemical process that is regulated in four dimensions. We distinguish parts
of the cycle: development describes the changes from single cell to adult, and aging the …

In mammals, circadian oscillators exist not only in the suprachiasmatic nucleus, which
harbors the central pacemaker, but also in most peripheral tissues. It is believed that the …

Circadian oscillations in mammalian physiology and behavior are regulated by an
endogenous biological clock. Here we show that loss of the PAS protein MOP3 (also known …