Development of NK cell-based cancer immunotherapies through receptor engineering

A Page, N Chuvin, J Valladeau-Guilemond… - Cellular & Molecular …, 2024 - nature.com
Natural killer (NK) cell-based immunotherapies are attracting increasing interest in the field
of cancer treatment. Early clinical trials have shown promising outcomes, alongside …

Chimeric antigen receptor therapy meets mRNA technology

J Wu, W Wu, B Zhou, B Li - Trends in Biotechnology, 2024 - cell.com
Genetically engineered immune cells expressing chimeric antigen receptors (CARs) have
emerged as a new game changer in cancer immunotherapy. The utility of CAR T cell therapy …

Immunotherapy in hematologic malignancies: achievements, challenges and future prospects

L Tang, Z Huang, H Mei, Y Hu - Signal Transduction and Targeted …, 2023 - nature.com
The immune-cell origin of hematologic malignancies provides a unique avenue for the
understanding of both the mechanisms of immune responsiveness and immune escape …

Advancements in CAR-NK therapy: lessons to be learned from CAR-T therapy

MK Kilgour, DJ Bastin, SH Lee, M Ardolino… - Frontiers in …, 2023 - frontiersin.org
Advancements in chimeric antigen receptor engineered T-cell (CAR-T) therapy have
revolutionized treatment for several cancer types over the past decade. Despite this success …

Chimeric antigen receptor engineered natural killer cells for cancer therapy

Y Zhang, W Zhou, J Yang, J Yang, W Wang - Experimental Hematology & …, 2023 - Springer
Natural killer (NK) cells, a unique component of the innate immune system, are inherent
killers of stressed and transformed cells. Based on their potent capacity to kill cancer cells …

Next‐generation chimeric antigen receptors for T‐and natural killer‐cell therapies against cancer

Y Li, K Rezvani, H Rafei - Immunological Reviews, 2023 - Wiley Online Library
Adoptive cellular therapy using chimeric antigen receptor (CAR) T cells has led to a
paradigm shift in the treatment of various hematologic malignancies. However, the broad …

Chimeric antigen receptor-engineered NK cells: new weapons of cancer immunotherapy with great potential

X Wang, X Yang, X Yuan, W Wang, Y Wang - Experimental Hematology & …, 2022 - Springer
Chimeric antigen receptor (CAR)-engineered T (CAR-T) cells have obtained prominent
achievement in the clinical immunotherapy of hematological malignant tumors, leading to a …

CAR-NK as a rapidly developed and efficient immunotherapeutic strategy against cancer

M Włodarczyk, B Pyrzynska - Cancers, 2022 - mdpi.com
Simple Summary New approaches in adoptive immunotherapy using chimeric antigen
receptor (CAR)-modified cells have been developing very quickly in recent years, entering …

Advances in CAR-NK cell therapy for hematological malignancies

R Yang, Y Yang, R Liu, Y Wang, R Yang… - Frontiers in …, 2024 - frontiersin.org
Chimeric antigen receptor T (CAR-T) cell therapy has revolutionized the treatment of
hematological malignancies, demonstrably improving patient outcomes and prognosis …

CAR NK cells: the future is now

MJ Raftery, AS Franzén, G Pecher - Annual Review of Cancer …, 2023 - annualreviews.org
Chimeric antigen receptor (CAR) T cell therapy has been a great success in CD19+
hematological diseases. Natural killer (NK) CAR cells offer an alternative to CAR T cells with …