Infectious diseases and cancer are among the key medical challenges that humankind is
facing today. A growing amount of evidence suggests that ion channels in the …

In comparison with normal cells, cancer cells are equipped with a higher number of
lysosomes, involved in degradative and non-degradative roles. In particular, the lysosome is …

Background Breast cancer is one of the most serious and prevalent malignancies. Zinc is
commonly known to play a crucial role in the development and progression of breast cancer; …

The significance of inflammation in tumorigenesis and progression has become prominent.
This study aimed to construct and validate the molecular subtype and a novel prognostic …

The importance of Ca 2+ signaling, and particularly Ca 2+ channels, in key events of cancer
cell function such as proliferation, metastasis, autophagy and angiogenesis, has recently …

Background Although national efforts are underway to document the genomic variability of
the Saudi population relative to other populations, such variability remains largely …

Two pore channels are lysosomal cation channels with crucial roles in tumor angiogenesis
and viral release from endosomes. Inhibition of the two-pore channel 2 (TPC2) has emerged …

The ion channel two‐pore channel 2 (TPC2), localised on the membranes of acidic
organelles such as endo‐lysosomes and melanosomes, has been shown to play a role in …

Zusammenfassung Durch Fortschritte im Bereich der Genomik kam es in den letzten drei
Jahrzehnten zu einer erheblichen Senkung der Kosten von Genomsequenzierungen. Durch …

This study was conducted to explore the correlations between the expression, methylation,
and various clinicopathological factors of purinergic P2X1 receptor (P2RX1) and the …