Current models for the folding of the human genome see a hierarchy stretching down from
chromosome territories, through A/B compartments and topologically-associating domains …

It has been hypothesized that SMC protein complexes such as condensin and cohesin
spatially organize chromosomes by extruding DNA into large loops. We directly visualized …

Chromosome organization poses a remarkable physical problem with many biological
consequences: How can molecular interactions between proteins at the nanometer scale …

The genome replication process is challenged at many levels. Replication must proceed
through different problematic sites and obstacles, some of which can pause or even reverse …

Structural maintenance of chromosome (SMC) protein complexes are the key organizers of
the spatiotemporal structure of chromosomes. The condensin SMC complex has recently …

Biomolecules such as nucleic acids and proteins constitute the cells and its organelles that
form the crucial components in all living organisms. They are associated with a variety of …

Antagonistic coevolution, arising from genetic conflict, can drive rapid evolution and
biological innovation. Conflict can arise both between organisms and within genomes. This …

SMC complexes are believed to be key universal mechanochemical motor proteins that
extrude DNA loops processively using ATP hydrolysis, contributing to macroscale …

The Escherichia coli CrfC protein is an important regulator of nucleoid positioning and
equipartition. Previously we revealed that CrfC homo-oligomers bind the clamp, a DNA …

SUMMARY Structural Maintenance of Chromosome (SMC) protein complexes are the key
organizers of the spatiotemporal structure of chromosomes. The condensin SMC complex …