"... It is likely that the leukocyte granulations are in fact secretory products, which the cell
dissolves and spreads to the environment as needed", Paul Ehrlich, 1900. Neutrophil …

We have discussed more than 30 mutant genes known to cause abnormalities in the
development and regulation of the immune system. The loci defined by these deleterious …

Reports that interleukin-8 (IL-8) induces the infiltration of neutrophils followed by T-cells into
injection sites led us to postulate that by stimulation of neutrophil degranulation IL-8 may …

VESICULAR transport to and from the lysosome and late endosome is defective in patients
with Chediak–Higashi syndrome (CHS) and in mutant beige (bg) mice1–4. CHS and bg …

We have devised a sensitive means to assess the antitumor effect of cytokines that act via
the mobilization of host-mediated defenses. This assay involves transfecting malignant cells …

Although immunosuppressive therapy minimizes the risk of graft failure due to acute
rejection, transplant-associated arteriosclerosis of the coronary arteries remains a significant …

The beige mutation in C57BL/6 mice has been shown to increase the susceptibility to
infection by Mycobacterium avium. In this study, we confirmed those results and showed that …

Natural killer (NK) cells cloned in vitro have been transferred into NK-deficient hosts. These
cells have been shown to have a role in the rejection of allogeneic bone marrow grafts …

Cancer immunosurveillance eradicates certain neoplasms, but the selective pressure
exerted by this active surveillance leads to the emergence of immune evasive tumor clones …

Tumor-induced immune suppression involves the accumulation of immune-suppressive
infiltrates in the microenvironment. This study demonstrates increased numbers of CD4+ …