The expanding universe of PARP1-mediated molecular and therapeutic mechanisms
D Huang, WL Kraus - Molecular cell, 2022 - cell.com
ADP-ribosylation (ADPRylation) is a post-translational modification of proteins catalyzed by
ADP-ribosyl transferase (ART) enzymes, including nuclear PARPs (eg, PARP1 and PARP2) …
ADP-ribosyl transferase (ART) enzymes, including nuclear PARPs (eg, PARP1 and PARP2) …
Epigenetics, DNA damage, and aging
C Soto-Palma, LJ Niedernhofer… - The Journal of …, 2022 - Am Soc Clin Investig
Over the course of a human lifespan, genome integrity erodes, leading to an increased
abundance of several types of chromatin changes. The abundance of DNA lesions …
abundance of several types of chromatin changes. The abundance of DNA lesions …
PARP1: liaison of chromatin remodeling and transcription
W Zong, Y Gong, W Sun, T Li, ZQ Wang - Cancers, 2022 - mdpi.com
Simple Summary Poly (ADP-ribose) polymerase 1 (PARP1) is perhaps the most studied
member of the PARP superfamily and participates in numerous cellular processes. PARP1 …
member of the PARP superfamily and participates in numerous cellular processes. PARP1 …
PARylated PDHE1α generates acetyl-CoA for local chromatin acetylation and DNA damage repair
Chromatin relaxation is a prerequisite for the DNA repair machinery to access double-strand
breaks (DSBs). Local histones around the DSBs then undergo prompt changes in …
breaks (DSBs). Local histones around the DSBs then undergo prompt changes in …
Histone H2A variants: Diversifying chromatin to ensure genome integrity
P Oberdoerffer, KM Miller - Seminars in cell & developmental biology, 2023 - Elsevier
Histone variants represent chromatin components that diversify the structure and function of
the genome. The variants of H2A, primarily H2A. X, H2A. Z and macroH2A, are well …
the genome. The variants of H2A, primarily H2A. X, H2A. Z and macroH2A, are well …
The GATAD2B-NuRD complex drives DNA: RNA hybrid-dependent chromatin boundary formation upon DNA damage
Double-strand breaks (DSBs) are the most lethal form of DNA damage. Transcriptional
activity at DSBs, as well as transcriptional repression around DSBs, are both required for …
activity at DSBs, as well as transcriptional repression around DSBs, are both required for …
Metabolic modulation of transcription: The role of one-carbon metabolism
While it is well known that expression levels of metabolic enzymes regulate the metabolic
state of the cell, there is mounting evidence that the converse is also true, that metabolite …
state of the cell, there is mounting evidence that the converse is also true, that metabolite …
Functions and interactions of mammalian KDM5 demethylases
E Pavlenko, T Ruengeler, P Engel, S Poepsel - Frontiers in genetics, 2022 - frontiersin.org
Mammalian histone demethylases of the KDM5 family are mediators of gene expression
dynamics during developmental, cellular differentiation, and other nuclear processes. They …
dynamics during developmental, cellular differentiation, and other nuclear processes. They …
[HTML][HTML] Targeting the DNA damage response (DDR) of cancer cells with natural compounds derived from Panax ginseng and other plants
SG Choi, M Shin, WY Kim - Journal of Ginseng Research, 2024 - Elsevier
DNA damage is a driver of cancer formation, leading to the impairment of repair
mechanisms in cancer cells and rendering them susceptible to DNA-damaging therapeutic …
mechanisms in cancer cells and rendering them susceptible to DNA-damaging therapeutic …
Domain architecture and protein–protein interactions regulate KDM5A recruitment to the chromatin
A Kataria, S Tyagi - Epigenetics, 2023 - Taylor & Francis
Tri-methylation of Histone 3 lysine 4 (H3K4) is an important epigenetic modification whose
deposition and removal can affect the chromatin at structural and functional levels. KDM5A …
deposition and removal can affect the chromatin at structural and functional levels. KDM5A …