ADP-ribosylation (ADPRylation) is a post-translational modification of proteins catalyzed by
ADP-ribosyl transferase (ART) enzymes, including nuclear PARPs (eg, PARP1 and PARP2) …

Over the course of a human lifespan, genome integrity erodes, leading to an increased
abundance of several types of chromatin changes. The abundance of DNA lesions …

Simple Summary Poly (ADP-ribose) polymerase 1 (PARP1) is perhaps the most studied
member of the PARP superfamily and participates in numerous cellular processes. PARP1 …

Chromatin relaxation is a prerequisite for the DNA repair machinery to access double-strand
breaks (DSBs). Local histones around the DSBs then undergo prompt changes in …

Histone variants represent chromatin components that diversify the structure and function of
the genome. The variants of H2A, primarily H2A. X, H2A. Z and macroH2A, are well …

Double-strand breaks (DSBs) are the most lethal form of DNA damage. Transcriptional
activity at DSBs, as well as transcriptional repression around DSBs, are both required for …

While it is well known that expression levels of metabolic enzymes regulate the metabolic
state of the cell, there is mounting evidence that the converse is also true, that metabolite …

Mammalian histone demethylases of the KDM5 family are mediators of gene expression
dynamics during developmental, cellular differentiation, and other nuclear processes. They …

DNA damage is a driver of cancer formation, leading to the impairment of repair
mechanisms in cancer cells and rendering them susceptible to DNA-damaging therapeutic …

Tri-methylation of Histone 3 lysine 4 (H3K4) is an important epigenetic modification whose
deposition and removal can affect the chromatin at structural and functional levels. KDM5A …