Small but Highly Versatile: The Viral Accessory Protein Vpu
M Volcic, L Wiesmüller, F Kirchhoff - Annual Review of Virology, 2023 - annualreviews.org
Human and simian immunodeficiency viruses (HIVs and SIVs, respectively) encode several
small proteins (Vif, Vpr, Nef, Vpu, and Vpx) that are called accessory because they are not …
small proteins (Vif, Vpr, Nef, Vpu, and Vpx) that are called accessory because they are not …
The combination of three CD4-induced antibodies targeting highly conserved Env regions with a small CD4-mimetic achieves potent ADCC activity
The majority of naturally elicited antibodies against the HIV-1 envelope glycoproteins (Env)
are non-neutralizing (nnAbs) because they are unable to recognize the Env trimer in its …
are non-neutralizing (nnAbs) because they are unable to recognize the Env trimer in its …
Unpredicted protective function of Fc-mediated inhibitory antibodies for HIV and SARS-CoV-2 vaccines
LY Lin, P Gantner, S Li, B Su… - The Journal of Infectious …, 2024 - academic.oup.com
Developing effective vaccines is necessary in combating new virus pandemics. For human
immunodeficiency virus (HIV) and severe acute respiratory syndrome coronavirus 2 (SARS …
immunodeficiency virus (HIV) and severe acute respiratory syndrome coronavirus 2 (SARS …
CD4 downregulation precedes Env expression and protects HIV-1-infected cells from ADCC mediated by non-neutralizing antibodies
ABSTRACT HIV-1 envelope glycoprotein (Env) conformation substantially impacts antibody-
dependent cellular cytotoxicity (ADCC). Envs from primary HIV-1 isolates adopt a prefusion …
dependent cellular cytotoxicity (ADCC). Envs from primary HIV-1 isolates adopt a prefusion …
Potent antibody-dependent cellular cytotoxicity of a V2-specific antibody is not sufficient for protection of macaques against SIV challenge
MW Grunst, HM Gil, AG Grandea III, BJ Snow… - Plos …, 2024 - journals.plos.org
Fc-mediated antibody effector functions, such as antibody-dependent cellular cytotoxicity
(ADCC), can contribute to the containment HIV-1 replication but whether such activities are …
(ADCC), can contribute to the containment HIV-1 replication but whether such activities are …
Antibody-dependent cellular cytotoxicity, infected cell binding and neutralization by antibodies to the SIV envelope glycoprotein
Antibodies specific for diverse epitopes of the simian immunodeficiency virus envelope
glycoprotein (SIV Env) have been isolated from rhesus macaques to provide physiologically …
glycoprotein (SIV Env) have been isolated from rhesus macaques to provide physiologically …
Impact of HIV-1 Vpu-mediated downregulation of CD48 on NK-cell-mediated antibody-dependent cellular cytotoxicity
ABSTRACT HIV-1 evades antibody-dependent cellular cytotoxicity (ADCC) responses not
only by controlling Env conformation and quantity at the cell surface but also by altering NK …
only by controlling Env conformation and quantity at the cell surface but also by altering NK …
Piperidine CD4-mimetic compounds expose vulnerable Env epitopes sensitizing HIV-1-infected cells to ADCC
The ability of the HIV-1 accessory proteins Nef and Vpu to decrease CD4 levels contributes
to the protection of infected cells from antibody-dependent cellular cytotoxicity (ADCC) by …
to the protection of infected cells from antibody-dependent cellular cytotoxicity (ADCC) by …
Higher HIV-1 Env gp120-specific antibody-dependent cellular cytotoxicity (ADCC) activity is associated with lower levels of defective HIV-1 provirus
R Yucha, ML Litchford, CS Fish, ZA Yaffe… - Viruses, 2023 - mdpi.com
A cure for HIV-1 (HIV) remains unrealized due to a reservoir of latently infected cells that
persist during antiretroviral therapy (ART), with reservoir size associated with adverse health …
persist during antiretroviral therapy (ART), with reservoir size associated with adverse health …
[HTML][HTML] NTB-A and 2B4 Natural Killer Cell Receptors Modulate the Capacity of a Cocktail of Non-Neutralizing Antibodies and a Small CD4-Mimetic to Eliminate HIV-1 …
L Marchitto, A Tauzin, M Benlarbi… - Viruses, 2024 - mdpi.com
Natural Killer (NK) cells have the potential to eliminate HIV-1-infected cells by antibody-
dependent cellular cytotoxicity (ADCC). NK cell activation is tightly regulated by the …
dependent cellular cytotoxicity (ADCC). NK cell activation is tightly regulated by the …