The WAVE regulatory complex (WRC), composed of five components—Cyfip1/Sra1,
WAVE/Scar, Abi, Nap1/Nckap1, and Brk1/HSPC300—is essential for proper actin …

Cyclic adenosine monophosphate (cAMP) signaling integrates information from diverse G-
protein-coupled receptors, such as neuromodulator receptors, to regulate pivotal biological …

Synapses are specialized intercellular junctions connecting pre-and postsynaptic neurons
into functional neural circuits. Synaptic cell adhesion molecules (CAMs) constitute key …

Combinatorial networks of cell adhesion molecules and cell surface receptors drive
fundamental aspects of neural circuit establishment and function. However, the intracellular …

Bidirectional trans‐synaptic signaling is essential for the formation, maturation, and plasticity
of synaptic connections. Synaptic cell adhesion molecules (CAMs) are prime drivers in …

Latrophilin-1 (Lphn1, aka CIRL1 and CL1; gene symbol Adgrl1) is an adhesion GPCR that
has been implicated in excitatory synaptic transmission as a candidate receptor for α …

Background Homo-and heteromerization of G protein-coupled receptors (GPCRs) plays an
important role in the regulation of receptor functions. Recently, we demonstrated an …

Homeostatic plasticity mechanisms act in a negative feedback manner to stabilize neuronal
firing around a set point. Classically, homeostatic synaptic plasticity is elicited via rather …

Neuronal information processing depends on converting membrane depolarizations into
compartmentalized biochemical signals that can modify neuronal activity and structure …

Multiple synaptic adhesion proteins are thought to collectively define the properties of
specific synapses and thereby shape the architectures of neural circuits. Growing evidence …