Salivary glands produce and secrete saliva, which is essential for maintaining oral health
and overall health. Understanding both the unique structure and physiological function of …

CD34 is a transmembrane phosphoglycoprotein, first identified on hematopoietic stem and
progenitor cells. Clinically, it is associated with the selection and enrichment of …

Radiotherapy remains a mainstay of cancer treatment, being used in roughly 50% of
patients. The precision with which the radiation dose can be delivered is rapidly improving …

This paper presents the etiopathogenesis, symptomatology, evaluation and treatment of
mouth dryness. Xerostomia affects 1-29% of the population, mostly women. It is observed in …

Adult stem cells are the ultimate source for replenishment of salivary gland (SG) tissue. Self-
renewal ability of stem cells is dependent on extrinsic niche signals that have not been …

Adult stem cells are often touted as therapeutic agents in the regenerative medicine field,
however data detailing both the engraftment and functional capabilities of solid tissue …

Radiotherapy for head and neck cancer is associated with impairment of salivary gland
function and consequent xerostomia, which has a devastating effect on the quality of life of …

Background The most manifest long-term consequences of radiation therapy in the head
and neck cancer patient are salivary gland hypofunction and a sensation of oral dryness …

Abstract Treatment of head and neck cancers (HNCs) involves radiotherapy. Patients
undergoing radiotherapy for HNCs are prone to dental complications. Radiotherapy to the …

Current dogma suggests that salivary gland homeostasis is stem cell dependent. However,
the extent of stem cell contribution to salivary gland maintenance has not been determined …