Inducing mucosal IgA: a challenge for vaccine adjuvants and delivery systems

PN Boyaka - The Journal of Immunology, 2017 - journals.aai.org
Abstract Mucosal IgA or secretory IgA (SIgA) are structurally equipped to resist chemical
degradation in the harsh environment of mucosal surfaces and enzymes of host or microbial …

Adjuvants and delivery systems based on polymeric nanoparticles for mucosal vaccines

Z Jin, S Gao, X Cui, D Sun, K Zhao - International journal of pharmaceutics, 2019 - Elsevier
Most pathogens enter the body through mucosal surfaces. Therefore, vaccination through
the mucosal route can greatly enhance the mucosal immune response. Vaccination via the …

When therapeutic IgA antibodies might come of age

D Sterlin, G Gorochov - Pharmacology, 2021 - karger.com
Background: Extensive efforts have been made in optimizing monoclonal immunoglobulin
(Ig) G antibodies for use in clinical practice. Accumulating evidence suggests that IgA or anti …

[HTML][HTML] The mucoadhesive nanoparticle-based delivery system in the development of mucosal vaccines

K Zhao, Y Xie, X Lin, W Xu - International Journal of Nanomedicine, 2022 - ncbi.nlm.nih.gov
Mucosal tissue constitutes the largest interface between the body and the external
environment, regulating the entry of pathogens, particles, and molecules. Mucosal …

Mucosal vaccination: Onward and upward

CJY Tsai, JMS Loh, K Fujihashi… - Expert Review of …, 2023 - Taylor & Francis
Introduction The unique mucosal immune system allows the generation of robust protective
immune responses at the front line of pathogen encounters. The needle-free delivery route …

Promising adjuvants and platforms for influenza vaccine development

W Zhu, C Dong, L Wei, BZ Wang - Pharmaceutics, 2021 - mdpi.com
Influenza is one of the major threats to public health. Current influenza vaccines cannot
provide effective protection against drifted or shifted influenza strains. Researchers have …

Nanovaccines to combat drug resistance: the next-generation immunisation

K Manju, SN Raj, HK Ranjini, SC Nayaka… - Future Journal of …, 2023 - Springer
Background The present review envisages the role of nanovaccines to combat the global
challenges of antimicrobial resistance. Nanovaccines are a novel formulation comprised of …

Mucosal and systemic immune responses to influenza H7N9 antigen HA1–2 co-delivered intranasally with flagellin or polyethyleneimine in mice and chickens

L Song, D Xiong, H Song, L Wu, M Zhang… - Frontiers in …, 2017 - frontiersin.org
Consecutive cases of human infection with H7N9 influenza viruses since 2013 in China
have prompted efforts to develop an effective treatment. Subunit vaccines introduced by …

Evaluation of the protective efficacy of Poly I: C as an adjuvant for H9N2 subtype Avian influenza inactivated vaccine and its mechanism of action in ducks

A Zhang, H Lai, J Xu, W Huang, Y Liu, D Zhao… - PLoS One, 2017 - journals.plos.org
Current commercial H9 avian influenza vaccines cannot provide satisfactory protective
immunity against antigenic variant influenza viruses in ducks. Poly I: C, when used as an …

Eye infection with SARS-CoV-2 as a route to systemic immunization?

N Schrage, J Blomet, F Holzer, A Tromme, F Ectors… - Viruses, 2022 - mdpi.com
Infectious diseases of the conjunctiva and cornea usually leave behind both broad local and
systemic immunity. Case reports of SARS-CoV-2-positive conjunctivitis with subsequent …