Mechanisms of nanoparticle transport across intestinal tissue: an oral delivery perspective
Oral drug administration has been a popular choice due to patient compliance and limited
clinical resources. Orally delivered drugs must circumvent the harsh gastrointestinal (GI) …
clinical resources. Orally delivered drugs must circumvent the harsh gastrointestinal (GI) …
[HTML][HTML] Lymphatic vessel network structure and physiology
The lymphatic system is comprised of a network of vessels interrelated with lymphoid tissue,
which has the holistic function to maintain the local physiologic environment for every cell in …
which has the holistic function to maintain the local physiologic environment for every cell in …
From sewer to saviour—targeting the lymphatic system to promote drug exposure and activity
The lymphatic system serves an integral role in fluid homeostasis, lipid metabolism and
immune control. In cancer, the lymph nodes that drain solid tumours are a primary site of …
immune control. In cancer, the lymph nodes that drain solid tumours are a primary site of …
Strategies to address low drug solubility in discovery and development
Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …
therefore, to variability in clinical response. Despite significant efforts to “design in” …
Lymphatic system in cardiovascular medicine
The mammalian circulatory system comprises both the cardiovascular system and the
lymphatic system. In contrast to the blood vascular circulation, the lymphatic system forms a …
lymphatic system. In contrast to the blood vascular circulation, the lymphatic system forms a …
Interstitial fluid and lymph formation and transport: physiological regulation and roles in inflammation and cancer
The interstitium describes the fluid, proteins, solutes, and the extracellular matrix (ECM) that
comprise the cellular microenvironment in tissues. Its alterations are fundamental to …
comprise the cellular microenvironment in tissues. Its alterations are fundamental to …
Meningeal lymphatics clear erythrocytes that arise from subarachnoid hemorrhage
J Chen, L Wang, H Xu, L Xing, Z Zhuang… - Nature …, 2020 - nature.com
Extravasated erythrocytes in cerebrospinal fluid (CSF) critically contribute to the
pathogenesis of subarachnoid hemorrhage (SAH). Meningeal lymphatics have been …
pathogenesis of subarachnoid hemorrhage (SAH). Meningeal lymphatics have been …
Methods of delivering mechanical stimuli to organ-on-a-chip
Recent advances in integrating microengineering and tissue engineering have enabled the
creation of promising microengineered physiological models, known as organ-on-a-chip …
creation of promising microengineered physiological models, known as organ-on-a-chip …
Lymphatic transport of high-density lipoproteins and chylomicrons
GJ Randolph, NE Miller - The Journal of clinical …, 2014 - Am Soc Clin Investig
The life cycles of VLDLs and most LDLs occur within plasma. By contrast, the role of HDLs in
cholesterol transport from cells requires that they readily gain access to and function within …
cholesterol transport from cells requires that they readily gain access to and function within …
Transmural flow modulates cell and fluid transport functions of lymphatic endothelium
Rationale: Lymphatic transport of peripheral interstitial fluid and dendritic cells (DCs) is
important for both adaptive immunity and maintenance of tolerance to self-antigens …
important for both adaptive immunity and maintenance of tolerance to self-antigens …