Stroke, the third leading cause of death and disability worldwide, is undergoing a change in
perspective with the emergence of new ideas on neurodegeneration. The concept that …

A plethora of neurological disorders shares a final common deadly pathway known as
excitotoxicity. Among these disorders, ischemic injury is a prominent cause of death and …

Neuroinflammation is initiated in response to ischemic stroke, and is usually characterized
by microglial activation and polarization. Stimulator of interferon genes (STING) has been …

Stroke is the leading cause of death and physical disability worldwide. Mitochondrial
dysfunction has been considered as one of the hallmarks of ischemic stroke and contributes …

Recanalization therapy is increasingly used in the treatment of acute ischemic stroke.
However, in about one third of these patients, recanalization is followed by …

The blood‐brain barrier (BBB), as a crucial gate of brain‐blood molecular exchange, is
involved in the pathogenesis of multiple neurological diseases. Oxidative stress is caused …

Background Ischemic stroke can induce changes in mitochondrial morphology and function.
As a regulatory gene in mitochondria, optic atrophy 1 (OPA1) plays a pivotal role in the …

Mitochondria are the “gatekeeper” in a wide range of cellular functions, signaling events, cell
homeostasis, proliferation, and apoptosis. Consequently, mitochondrial injury is linked to …

Autophagy is a conserved process to maintains homeostasis via the degradation of toxic cell
contents, which can either promote cell survival or accelerate cellular demise. Ferroptosis is …

The accumulation of dysfunctional mitochondria induced by the impairment of the autophagy-
lysosome pathway (ALP), especially mitophagy is an important cause of cerebral ischemia …