The abnormal regulation of alternative splicing is usually accompanied by the occurrence
and development of tumors, which would produce multiple different isoforms and diversify …

Protein–RNA interactions have crucial roles in various cellular activities, which, when
dysregulated, can lead to a range of human diseases. The identification of small molecules …

Tumor-associated alterations in RNA splicing result either from mutations in splicing-
regulatory elements or changes in components of the splicing machinery. This review …

Splicing of the precursor messenger RNA, involving intron removal and exon ligation, is
mediated by the spliceosome. Together with biochemical and genetic investigations of the …

Simple Summary The well-known tumor suppressor protein p53 plays important roles in
tumor prevention through transcriptional regulation of its target genes. Reactivation of p53 …

Alternative splicing (AS) of mRNAs is an essential regulatory mechanism in eukaryotic gene
expression. AS misregulation, caused by either dysregulation or mutation of splicing factors …

Over the course of more than two decades, natural products isolated from various
microorganisms and plants have built the foundation for chemical biology research into the …

Approximately half of genetic disease-associated mutations cause aberrant splicing.
However, a widely applicable therapeutic strategy to splicing diseases is yet to be …

Tumor cells alter their metabolism by a wide array of mechanisms to promote growth and
proliferation. Dysregulated expression and/or somatic mutations of key components of the …

ABSTRACT RNA processing plays a key role in gene expression, allowing for increased
protein diversity and functional complexity. Consequently, modulating RNA processing can …