The Nr4a family of nuclear hormone receptors is composed of three members—
Nr4a1/Nur77, Nr4a2/Nurr1 and Nr4a3/Nor1. While currently defined as ligandless, these …

As organisms age, cells accumulate genetic and epigenetic errors that eventually lead to
impaired organ function or catastrophic transformation such as cancer. Because aging …

Arterial media calcification is related to mitochondrial dysfunction. Protective mitophagy
delays the progression of vascular calcification. We previously reported that lactate …

Objective To assess geniposide's effects in New Zealand rabbits with high-fat diet induced
atherosclerosis and to explore the underpinning mechanisms. Materials and methods Aorta …

Background Oxidative stress plays critical pathophysiological roles in vascular remodeling-
related cardiovascular diseases, including hypertension, atherosclerosis, and restenosis …

Intestinal fibrosis is a common complication of the inflammatory bowel diseases (IBDs),
contributing to tissue stiffening and luminal narrowing. Human nuclear receptor 4A 1 …

Objective Hemodynamics-induced low wall shear stress (WSS) is one of the critical reasons
leading to vascular remodeling. However, the coupling effects of WSS and cellular kinetics …

Although great efforts to characterize the embryonic phase of brain microvascular system
development have been made, its postnatal maturation has barely been described. Here …

Objective In young patients, aortic valve disease is often treated by placement of a
pulmonary autograft (PA) which adapts to its new environment through growth and …

Atherosclerosis is a cardiovascular disease that seriously endangers human health. Low
shear stress (LSS) is recognized as a vital factor in causing chronic inflammatory and further …